Hair Follicle Plasticity with Complemented Immune-Modulation Following Follicular Unit Extraction

    Reza P. Azar, Alexander Thomas, G Lindner
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    TLDR Transplanted hair follicles can change and adapt to new areas of the body, with the immune system possibly playing a role in this adjustment.
    The study examined the adaptability and immune response of hair follicles transplanted to different sites using follicular unit extraction (FUE) in two male patients. One patient had chest, beard, and scalp hair moved to the scalp, while the other had beard hair moved to the eyebrows. After 6 months, the transplanted follicles were analyzed and showed significant morphological changes, adapting to their new location with a reduction in follicle length and dermal papilla size by about 20-30%. There was also a notable immune cell infiltration in the transplanted follicles, suggesting that the immune system may contribute to the tissue remodeling after transplantation. The study concluded that hair follicles can adjust to new environments and that the immune response is likely involved in this process. However, the small sample size of the study indicates that further research with more participants is necessary to confirm these findings.
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      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

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