Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness

November 2011 in “ British Journal of Dermatology ”

Felix F. Brockschmidt, Stefanie Heilmann, Justine A. Ellis, Sibylle Eigelshoven, S. Hanneken, Christine Herold, Susanne Moebus, Margrieta Alblas, Bärbel Lippke, Nadine Kluck, Lutz Priebe, Franziska Degenhardt, Rami Abou Jamra, Christian Meesters, Karl Heinz Jöckel, Raimund Erbel, Stephen B Harrap, Johannes Schumacher, Holger Fröhlich, Roland Kruse, Axel M. Hillmer, Tim Becker, Markus M. Nöthen

male-pattern baldness AGA chromosome 7p21.1 HDAC9 histone deacetylase 9 SNPs rs756853 rs2249817 hair follicles AR gene androgenic alopecia single nucleotide polymorphisms androgen receptor gene

Studysummary This study suggests that the HDAC9 gene is a third susceptibility gene for male-pattern baldness, with significant associations found in both German and Australian samples.

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