Genetic Variants at 20p11 Confer Risk to Androgenetic Alopecia in the Chinese Han Population

August 2013 in “ PLOS ONE ”

Bo Liang, Chunjun Yang, Xianbo Zuo, Yan Li, Yantao Ding, Yujun Sheng, Fusheng Zhou, Hui Cheng, Xiaodong Zheng, Gang Chen, Zhengwei Zhu, Jun Zhu, Fu Xuhui, Tao Wang, Ying Dong, Dawei Duan, Xianfa Tang, Huayang Tang, Jinping Gao, Liangdan Sun, Sen Yang, Xuejun Zhang

androgenetic alopecia genetic variants 20p11 single nucleotide polymorphisms SNPs rs2180439 HDAC9 gene PAX1 gene LD block long-range control AGA male-pattern baldness

TLDR Genetic variants at 20p11 increase baldness risk in Chinese Han people.

This study found that genetic variants at 20p11 confer a risk to androgenetic alopecia (AGA) in the Chinese Han population. The study analyzed five single nucleotide polymorphisms (SNPs) in 445 cases and 546 controls and found that the rs2180439 SNP was significantly associated with AGA. The study suggests that the HDAC9 gene may be a new candidate gene for male-pattern baldness. The study also found that the PAX1 gene may confer the AGA-relevant effect at this locus and that a regulatory variant within the associated LD block may modulate its expression through long-range control.

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