Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness

    May 2015 in “ PLOS ONE ”
    Magdalena Marcińska, Ewa Pośpiech, Sarah Abidi … Wojciech Branicki
    Studysummary This study found that a genetic test using 5 to 20 SNPs can predict male pattern baldness with variable accuracy in European men, especially those aged 50 and older.
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    Research cited in this study 24

    1. Age-Related Hair Changes in Men: Mechanisms and Management of Alopecia and Graying Maturitas · 2014
    2. Genetic Variants at 20p11 Confer Risk to Androgenetic Alopecia in the Chinese Han Population PLOS ONE · 2013
    3. Microarray Analysis of Androgenetic and Senescent Alopecia: Comparison of Gene Expression Shows Two Distinct Profiles Journal of Dermatological Science · 2013
    4. Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology Journal of Investigative Dermatology · 2013
    5. Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases PLOS Genetics · 2012
    6. Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss British Journal of Dermatology · 2012
    7. Characteristics of Androgenetic Alopecia in Asian Populations Annals of Dermatology · 2012
    8. Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness British Journal of Dermatology · 2011
    9. Androgen Receptor Gene Polymorphisms and Risk for Androgenetic Alopecia: A Meta-Analysis Clinical and Experimental Dermatology · 2011
    10. Evidence for Two Independent Functional Variants for Androgenetic Alopecia Around the Androgen Receptor Gene Experimental Dermatology · 2010
    11. Fine Mapping of the Human AR/EDA2R Locus in Androgenetic Alopecia British Journal of Dermatology · 2010
    12. Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans American journal of human genetics · 2009
    13. Recent Positive Selection of a Human Androgen Receptor/Ectodysplasin A2 Receptor Haplotype and Its Relationship to Male Pattern Baldness Human Genetics · 2009
    14. Combing the Genome for the Root Cause of Baldness Nature Genetics · 2008
    15. Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11 Nature Genetics · 2008
    16. Male-Pattern Baldness Susceptibility Locus at 20p11 Nature Genetics · 2008
    17. EDA2R Is Associated With Androgenetic Alopecia Journal of Investigative Dermatology · 2008
    18. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    19. The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia Cancer Epidemiology, Biomarkers & Prevention · 2005
    20. Genetic Basis of Male Pattern Baldness Journal of Investigative Dermatology · 2003
    21. Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness Journal of Investigative Dermatology · 2001
    22. Prevalence of Male Pattern Hair Loss in 18–49 Year Old Men Dermatologic Surgery · 1998
    23. Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes Journal of Investigative Dermatology · 1998
    24. The Inheritance Of Common Baldness: To Be Or Not To Be? Journal of the American Academy of Dermatology · 1984

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    1. Evaluation of DNA Variants Associated with Androgenetic Alopecia and Their Potential to Predict Male Pattern Baldness PLOS ONE · 2015