Genome-Wide Scan and Fine-Mapping Linkage Study of Androgenetic Alopecia Reveals a Locus on Chromosome 3q26

March 2008 in “ American Journal of Human Genetics ”

Axel M. Hillmer, Antonia Flaquer, Sandra Hanneken, Sibylle Eigelshoven, Anne-Katrin Kortüm, Felix F. Brockschmidt, Astrid Golla, Christine Metzen, Holger Thiele, Susanne Kolberg, Roman Reinartz, Regina C. Betz, Thomas Ruzicka, Hans Christian Hennies, Roland Kruse, Markus M. Nöthen

androgenetic alopecia AGA genetic loci chromosome 3q26 genetic factors male pattern baldness

TLDR Hair loss gene found on chromosome 3q26.

This study conducted a genome-wide scan and fine-mapping linkage study to identify genetic loci associated with androgenetic alopecia (AGA). The study found evidence for multiple genes contributing to AGA susceptibility, with a significant locus identified on chromosome 3q26. The study suggests that genetic factors play a significant role in the development of AGA. The study provides a first step towards identifying new genes contributing to the development of early onset AGA.

View this study on cell.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations, July 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research Early Onset of Androgenetic Alopecia Associated With Early Severe Coronary Heart Disease: A Population-Based, Case-Control Study

56 citations, June 2001 in “European journal of cardiovascular prevention & rehabilitation”

Early balding linked to higher heart disease risk.

research Early Androgenetic Alopecia as a Marker of Insulin Resistance

115 citations, September 2000 in “The Lancet”

Early hair loss may indicate risk of insulin resistance.

research Association of Benign Prostatic Hyperplasia with Male Pattern Baldness

54 citations, May 1998 in “Urology”

Men with enlarged prostates often have more severe baldness.

Related Community Posts Join

6 / 1000+ results

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 14 upvotes 4 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community AGA evaluation and first steps - BEGINNER MEGAPOST

in Chat 79 upvotes 5 months ago

The conversation discusses androgenic alopecia (AGA) and its treatments, focusing on finasteride, minoxidil, and ketoconazole shampoo. Finasteride is recommended as essential for preventing further hair loss.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 862 upvotes 3 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 97 upvotes 5 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 41 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

in Technology 107 upvotes 4 months ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

Similar Research

5 / 1000+ results

research Mapping of Cis-Acting Expression Quantitative Trait Loci in Human Scalp Hair Follicles

4 citations, November 2020 in “BMC Dermatology”

Researchers identified genes in scalp hair follicles that may affect hair traits and hair loss.

research Genomic Markers and Personalized Medicine in Androgenetic Alopecia: A Comprehensive Review

August 2024 in “Cosmetics”

Personalized treatments for hair loss are becoming more effective by using genetic information.

Update on the Genetics of Androgenetic Alopecia, Female Pattern Hair Loss, and Alopecia Areata: Implications for Molecular Diagnostic Testing

research Update on the Genetics of Androgenetic Alopecia, Female Pattern Hair Loss, and Alopecia Areata: Implications for Molecular Diagnostic Testing

11 citations, November 2012 in “Seminars in Cutaneous Medicine and Surgery”

Genetic factors affect hair loss, and molecular testing may help predict, diagnose, and treat it.

research Physiology and Medical Treatments for Alopecia

8 citations, April 2020 in “Facial Plastic Surgery Clinics of North America”

Minoxidil, finasteride, and low-level laser light therapy are effective FDA-approved treatments for hair loss.

research The Endocrinology of Baldness

19 citations, April 2014 in “Hormones”

Hormones and genetics play key roles in male and female baldness, which can affect mental health and may be linked to other health issues.