Hair of the Dog: Identification of a Cis-Regulatory Module Predicted to Influence Canine Coat Composition
April 2019
in “
Genes
”
genetic locus chromosome 28 SNP array whole genome sequence long noncoding RNA ADRB1 gene cis-regulatory module transcription factor binding GWAS variant mapping genetic location single nucleotide polymorphism whole genome sequencing noncoding RNA adrenoceptor beta 1 gene regulation genome-wide association study
TLDR Researchers found a genetic region that influences the number of coat layers in dogs.
Researchers identified a genetic locus on chromosome 28 associated with the number of coat layers in domestic dogs using SNP array and whole genome sequence data. They found an 18.4 kilobase region with 62 significant variants within a long noncoding RNA upstream of the ADRB1 gene, suggesting it acts as a cis-regulatory module. Two variants, common in single-coated dogs but rare in wolves, were predicted to affect transcription factor binding. This study was one of the first to use WGS data for GWAS and variant mapping to identify traits defining dog breeds.
