What Does Acne Genetics Teach Us About Disease Pathogenesis?

    March 2019 in “ British Journal of Dermatology ”
    John E.A. Common, Jonathan Barker, M.A.M. van Steensel
    Studysummary Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.
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    Research cited in this study 12

    1. Homeostasis of the Sebaceous Gland and Mechanisms of Acne Pathogenesis British Journal of Dermatology · 2019
    2. Analysis of Hidradenitis Suppurativa-Linked Mutations in Four Genes and the Effects of PSEN1-P242LfsX11 on Cytokine and Chemokine Expression in Macrophages Human Molecular Genetics · 2018
    3. Genome-Wide Meta-Analysis Implicates Mediators of Hair Follicle Development and Morphogenesis in Risk for Severe Acne Nature Communications · 2018
    4. Dermatologic Manifestations of Endocrine Disorders Translational pediatrics · 2017
    5. Endocrine Disorders and Hormonal Therapy for Adolescent Acne Current Opinion in Pediatrics · 2017
    6. Mutations in Gamma-Secretase Subunit-Encoding PSENEN Underlie Dowling-Degos Disease Associated with Acne Inversa Journal of Clinical Investigation · 2017
    7. Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions Advances in wound care · 2016
    8. C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis Cell reports · 2013
    9. Acne-Associated Syndromes: Models for Better Understanding of Acne Pathogenesis Journal of The European Academy of Dermatology and Venereology · 2010
    10. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    11. C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny Current Biology · 2001
    12. Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne Journal of Cutaneous Medicine and Surgery · 1998