What Does Acne Genetics Teach Us About Disease Pathogenesis?

March 2019 in “ British Journal of Dermatology ”

John E.A. Common, Jonathan Barker, M.A.M. van Steensel

acne vulgaris genetic loci genome-wide association studies GWAS androgen metabolism inflammation stem cell fate tissue remodeling Notch signaling pathway sebaceous gland function hormonal imbalances PCOS CAH monogenic disorders cell-based models acne polycystic ovary syndrome congenital adrenal hyperplasia

Studysummary Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

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