The Genetics of Acne

    July 2025 in “ Annals of Human Genetics ”
    Maurice A. M. Van Steensel
    Studysummary This review examines the genetics of acne vulgaris, concluding that stem/progenitor cell maintenance and cellular migration are key processes in its pathogenesis, potentially shifting future treatment strategies beyond traditional antibiotics and retinoids, which have notable side effects.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on onlinelibrary.wiley.com →
    Discuss this study in the Community →

    Research cited in this study 14

    1. Lrig1-Expressing Epidermal Progenitors Require SCD1 to Maintain the Dermal Papilla Niche Scientific reports · 2023
    2. TREM2 Macrophages Induced by Human Lipids Drive Inflammation in Acne Lesions Science Immunology · 2022
    3. Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2021
    4. Androgens and Acne: Perspectives on Clascoterone, the First Topical Androgen Receptor Antagonist Expert opinion on pharmacotherapy · 2021
    5. Homeostasis of the Sebaceous Gland and Mechanisms of Acne Pathogenesis British Journal of Dermatology · 2019
    6. What Does Acne Genetics Teach Us About Disease Pathogenesis? British Journal of Dermatology · 2019
    7. Genome-Wide Meta-Analysis Implicates Mediators of Hair Follicle Development and Morphogenesis in Risk for Severe Acne Nature Communications · 2018
    8. Genome-Wide Association Study in Japanese Females Identifies Fifteen Novel Skin-Related Trait Associations Scientific reports · 2018
    9. Sebaceous Lipids Are Essential for Water Repulsion, Protection Against UVB-Induced Apoptosis, and Ocular Integrity in Mice Development · 2016
    10. Strategic Targets in Acne: The Comedone Switch in Question Dermatology · 2015
    11. Involvement of Wnt, Eda, and Shh at Defined Stages of Sweat Gland Development Development · 2014
    12. C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis Cell reports · 2013
    13. Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells Gastroenterology · 2010
    14. The Role of Fibroblast Growth Factor Receptor 2b in Skin Homeostasis and Cancer Development The EMBO Journal · 2007