Hidradenitis Suppurativa, Acne Inversa, Dissecting Terminal Hair Folliculitis

    January 2019 in “ Springer eBooks ”
    Gerd Plewig, Bodo C. Melnik, WenChieh Chen
    Image of study
    TLDR Hidradenitis Suppurativa is a chronic skin condition best treated early with surgery for better outcomes and less recurrence.
    The document from January 1, 2019, discusses Dissecting Terminal Hair Folliculitis (DTHF), a chronic inflammatory skin condition affecting terminal hair follicles, more common in women and associated with obesity, smoking, and genetic factors. The condition is linked to autoimmune diseases and characterized by an increased Th17 cell/regulatory T-cell ratio, suggesting a proinflammatory predisposition. Genetic mutations in the y-secretase gene complex and impaired Treg-hair follicle stem cell interactions are implicated in hereditary cases. Treatments include antibiotics, anti-inflammatory drugs, and biologics like TNF-α blockers, but these often result in relapse. A combination of clindamycin and rifampicin showed a satisfactory response in 70-80% of patients with moderate disease, but 60% relapsed after 4 months. Surgical excision is the only curative treatment, with a much lower long-term recurrence rate (13-27%). Early diagnosis and surgical intervention are crucial for better outcomes, and the disease has a significant psychosocial impact on patients.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 12 results

      community Federal Grant Cuts have impacted PP405 related research

      in Technology  460 upvotes 4 weeks ago
      Federal funding cuts have delayed PP405 research, affecting hair loss treatment progress, though clinical trials will continue. The discussion highlights PP405's potential compared to minoxidil and finasteride and stresses the importance of government-funded research.

      community Verteporfin and Microneedling

      in Treatments 1 year ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 1 year ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

    Related Research

    1 / 1 results