66 citations
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March 2018 in “British journal of dermatology/British journal of dermatology, Supplement”
This article reviews the role of perifollicular regulatory T cells in maintaining hairfollicle integrity in the context of hidradenitis suppurativa and calls attention to inflammatory mechanisms without reporting new clinical results.
This study found that skin-resident Treg cells regulate hairfolliclestemcell proliferation and differentiation through the Jag1-Notch signaling pathway, influencing hair regeneration.
April 2024 in “The Journal of experimental medicine/The journal of experimental medicine”
This review discusses how regulatory T cells, known for their immunosuppressive role, also produce repair mediators critical for tissue repair and regeneration, acting on non-immune cells in tissue-specific contexts, and highlights areas for future research in tissue repair, fibrosis, and cancer.
2 citations
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September 2022 in “Frontiers in Immunology”
This article reviews the emerging non-inflammatory roles of regulatory T cells in the skin and reports no new clinical findings, suggesting broad biological influence beyond traditional immune functions.
Hairfollicle regeneration through stemcell rearrangement is discussed, focusing on bioengineered cellular structures rather than traditional hair transplants. Treatments mentioned include Minoxidil, finasteride, and RU58841.
Hair regrowth treatments, including stemcell injections, are discussed, with skepticism about their effectiveness compared to Minoxidil and finasteride. Derma stamping is mentioned as effective when used with Minoxidil, finasteride, and dutasteride.
Stemcellhair transplants use stem cells from fat tissue to reactivate inactive hair follicles, but results are inconsistent and not widely shared. Traditional treatments like finasteride and minoxidil often show better results.
Stemcell-related treatments and drugs like RCGD423 and WAY are being tested for hair growth. Clinics are conducting tests on patients who haven't had previous treatments.
Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.
Can stemcell factor be combined with other topical hair loss solutions?No published human trial has tested topical stem cell factor alongside minoxidil or other established treatments, so neither the safety nor the benefit of the combination has been established. Community users report layering these products, but that is anecdote rather than clinical evidence.
How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride?Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.