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GlossaryRegulatory T Cells (Tregs)

specialized immune cells that prevent autoimmune responses

Regulatory T Cells, often abbreviated as Tregs, are a specialized subset of T cells in the immune system that help maintain immune tolerance and prevent autoimmune diseases. They function by suppressing the activity of other immune cells, thereby preventing excessive or misdirected immune responses that could damage the body's own tissues.

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diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties

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research Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin

192 citations, March 2017 in “Cell host & microbe”

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

research Tregs: Where We Are and What Comes Next?

130 citations, November 2017 in “Frontiers in Immunology”

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

research Tissue Resident and Follicular Treg Cell Differentiation Is Regulated by CRAC Channels

40 citations, March 2019 in “Nature Communications”

CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.

CD4+CD25+FoxP3+ Regulatory Tregs Inhibit Fibrocyte Recruitment and Fibrosis via Suppression of FGF-9 Production in the TGF-β1 Exposed Murine Lung

research CD4+CD25+FoxP3+ Regulatory Tregs Inhibit Fibrocyte Recruitment and Fibrosis via Suppression of FGF-9 Production in the TGF-β1 Exposed Murine Lung

39 citations, May 2014 in “Frontiers in Pharmacology”

Special immune cells called Tregs can help prevent lung scarring by blocking a specific growth factor.

Decreased CD200R Expression on Monocyte-Derived Macrophages Correlates with Th17/Treg Imbalance and Disease Activity in Rheumatoid Arthritis Patients

research Decreased CD200R Expression on Monocyte-Derived Macrophages Correlates with Th17/Treg Imbalance and Disease Activity in Rheumatoid Arthritis Patients

31 citations, February 2014 in “Inflammation Research”

Lower CD200R1 on certain immune cells is linked to more severe rheumatoid arthritis and immune imbalance.

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