Lrig1-Expressing Epidermal Progenitors Require SCD1 to Maintain the Dermal Papilla Niche

March 2023 in “ Scientific reports ”

Sophia Beng Hui Lim, Wei Shang, Andy Hee-Meng Tan, Maurice A. M. Van Steensel, Xinhong Lim

Lrig1-expressing epidermal progenitors Stearoyl CoA Desaturase 1 SCD1 dermal papilla niche hair matrix progenitors anagen-catagen transition Wnt signaling Hedgehog signaling hair growth hair cycle

TLDR Hair growth-related cells need the enzyme SCD1 to help maintain the area that supports hair growth.

This document presents findings that suggest hair matrix progenitors and the enzyme Stearoyl CoA Desaturase 1 (SCD1) play a role in maintaining the dermal papilla niche, which is crucial for hair growth, during the anagen-catagen transition of the mouse hair cycle. The study indicates that this maintenance may occur through autocrine Wnt signaling and paracrine Hedgehog signaling. This is reported to be the first evidence of matrix progenitor cells' potential involvement in sustaining the dermal papilla niche.

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23 / 23 results

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4 / 4 results

Lrig1-Expressing Epidermal Progenitors Require SCD1 to Maintain the Dermal Papilla Niche

Cited in this study

research The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells

research Platelet-Derived Growth Factor Signaling Modulates Adult Hair Follicle Dermal Stem Cell Maintenance and Self-Renewal

research Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog

research Sebaceous Lipids Are Essential for Water Repulsion, Protection Against UVB-Induced Apoptosis, and Ocular Integrity in Mice

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

research Development and Homeostasis of the Sebaceous Gland

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

research Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

research De Novo Production of Dermal Papilla Cells During the Anagen Phase of the Hair Cycle

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

research A Missense Mutation in the P2RY5 Gene Leading to Autosomal Recessive Woolly Hair in a Syrian Patient

research SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

research Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia

research Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration

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research 17β-Estradiol and ICI-182780 Regulate the Hair Follicle Cycle in Mice Through an Estrogen Receptor-α Pathway

research An Estrogen Receptor Pathway Regulates the Telogen-Anagen Hair Follicle Transition and Influences Epidermal Cell Proliferation

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