Lrig1-Expressing Epidermal Progenitors Require SCD1 to Maintain the Dermal Papilla Niche

March 2023 in “ Scientific reports ”

Sophia Beng Hui Lim, Wei Shang, Andy Hee-Meng Tan, Maurice A. M. Van Steensel, Xinhong Lim

Lrig1-expressing epidermal progenitors Stearoyl CoA Desaturase 1 SCD1 dermal papilla niche hair matrix progenitors anagen-catagen transition Wnt signaling Hedgehog signaling hair growth hair cycle

Studysummary This study presents evidence that hair matrix progenitors and the enzyme Stearoyl CoA Desaturase 1 may play a role in maintaining the dermal papilla niche via autocrine Wnt and paracrine Hedgehog signaling in mice. Our plain-language summary of this paper — not a Tressless recommendation.

This document presents findings that suggest hair matrix progenitors and the enzyme Stearoyl CoA Desaturase 1 (SCD1) play a role in maintaining the dermal papilla niche, which is crucial for hair growth, during the anagen-catagen transition of the mouse hair cycle. The study indicates that this maintenance may occur through autocrine Wnt signaling and paracrine Hedgehog signaling. This is reported to be the first evidence of matrix progenitor cells' potential involvement in sustaining the dermal papilla niche.

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