Sebaceous Lipids Are Essential for Water Repulsion, Protection Against UVB-Induced Apoptosis, and Ocular Integrity in Mice

    January 2016 in “ Development ”
    Maik Dahlhoff, Emanuela Camera, Matthias Schäfer … Marlon R. Schneider
    Studysummary This study introduced Scd3-Cre mice, which enabled sebocyte-specific manipulation, revealing that sebaceous lipid depletion impaired water repulsion, thermoregulation, and the ocular surface, resembling Meibomian gland dysfunction.
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    Research cited in this study 10

    1. Cidea Control of Lipid Storage and Secretion in Mouse and Human Sebaceous Glands Molecular and Cellular Biology · 2014
    2. A Practical Guide for the Study of Human and Murine Sebaceous Glands In Situ Experimental Dermatology · 2013
    3. Sebocytes’ Makeup: Novel Mechanisms and Concepts in the Physiology of the Human Sebaceous Glands Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere/Pflügers Archiv · 2011
    4. Acute Sensitivity of the Oral Mucosa to Oncogenic K-ras Journal of pathology · 2011
    5. C/EBPα and C/EBPβ Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin PloS one · 2010
    6. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    7. Phylogeny of the Hair Follicle: The Sebogenic Hypothesis Journal of Investigative Dermatology · 2007
    8. Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2007
    9. Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia ˜The œAmerican journal of pathology · 2000
    10. 13-Cis-Retinoic Acid Affects Sheath-Shaft Interactions of Equine Hair Follicles In Vitro Journal of Investigative Dermatology · 1996

    Related research 3

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    2. Culture of the Human Pilosebaceous Unit, Hair Follicle, and Sebaceous Gland Experimental Dermatology · 2018
    3. Lineage Tracing of Hair Follicle Stem Cells in Epidermal Whole Mounts Methods in molecular biology · 2013