Acute Sensitivity of the Oral Mucosa to Oncogenic K-ras

March 2011 in “ Journal of pathology ”

Louise van der Weyden, Maria P. Alcolea, Philip H. Jones … David J. Adams

oncogenic K-ras hyperproliferative changes neoplastic changes squamous hyperplasia papillomas with dysplasia early invasive squamous cell carcinoma tamoxifen-inducible mouse model Ras/AKT pathway K-Ras/ERK pathway K-ras tamoxifen

Studysummary In this study, activation of oncogenic K-ras in a mouse model caused the oral mucosa to rapidly progress from squamous hyperplasia to carcinoma within 14 days, demonstrating its acute sensitivity.

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