Fibrotic Enzymes Modulate Wound-Induced Skin Tumorigenesis

    March 2021 in “ EMBO Reports ”
    Lisette Van Hove, Kim Lecomte, Jana Roels … Esther Hoste
    Studysummary PRSS35 enzyme may help start skin tumors and could be a target for cancer treatment.
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    Research cited in this study 6

    1. Fibrotic Enzymes Modulate Wound-Induced Skin Tumorigenesis EMBO Reports · 2021
    2. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    3. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    4. Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing Development · 2016
    5. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    6. Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin Development · 2011