TLDR PRSS35 enzyme may help start skin tumors and could be a target for cancer treatment.
The study explored the role of the enzyme PRSS35 in wound-induced skin tumorigenesis, revealing that cancer-associated fibroblasts (CAFs) in these tumors exhibited a fibrotic gene signature with high PRSS35 expression. Deleting PRSS35 in mice led to abnormal collagen composition and increased tumor incidence, suggesting its role in regulating tumor initiation by remodeling the extracellular matrix (ECM). PRSS35 was also upregulated in high-grade human squamous cell carcinomas, indicating its potential as a biomarker for tumor staging. The findings highlighted the importance of fibrotic responses in cancer progression and suggested PRSS35 as a potential therapeutic target.
15 citations
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March 2021 in “EMBO Reports” PRSS35 enzyme may help start skin tumors and could be a target for cancer treatment.
301 citations
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February 2019 in “Nature Communications” The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.
418 citations
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January 2018 in “Journal of Investigative Dermatology” Researchers found four distinct fibroblast types in human skin, which could help in treating wounds and fibrotic diseases.
87 citations
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January 2016 in “Development” Blocking β-catenin in skin cells improves hair growth during wound healing.
1235 citations
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December 2013 in “Nature” Two fibroblast types shape skin structure and repair differently.
128 citations
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October 2011 in “Development” Activating a protein called β-catenin in adult skin can make it behave like young skin, potentially helping with skin aging and hair loss.
1 citations
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August 2023 in “The Journal of Pathology” Different types of skin fibroblasts have unique roles in skin health and disease.
488 citations
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July 2021 in “Cell” Fibroblasts are crucial for tissue repair and inflammation, and understanding them can help treat fibrotic diseases.
2 citations
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October 2021 in “JID innovations” Uterine leiomyomas don't significantly change gene expression in the scalp of people with Central Centrifugal Cicatricial Alopecia.
128 citations
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August 2020 in “Cell stem cell” Dermal fibroblasts have adjustable roles in wound healing, with specific cells promoting regeneration or scar formation.
21 citations
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June 2016 in “Genesis” Researchers identified specific genes that are important for mouse skin cell development and healing.
