MSC-EVs and UCB-EVs Promote Skin Wound Healing and Spatial Transcriptome Analysis

    February 2025 in “ Scientific Reports ”
    Ruonan Li, Haotian Wang, Xiaolong Wang … Heping Li
    Studysummary This study found that extracellular vesicles derived from mesenchymal stem cells and umbilical cord blood plasma enhanced wound healing and reduced scar formation in mice, suggesting their potential as therapeutic agents for skin repair.
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    Research cited in this study 8

    1. Human Amniotic Fluid Stem Cell-Derived Exosomes as a Novel Cell-Free Therapy for Cutaneous Regeneration Frontiers in Cell and Developmental Biology · 2021
    2. Regeneration of Dermis: Scarring and Cells Involved Cells · 2019
    3. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    4. Scarless Wound Healing: Finding the Right Cells and Signals Cell and Tissue Research · 2016
    5. Wnt and Notch Signaling Pathway Involved in Wound Healing by Targeting c-Myc and Hes1 Separately Stem Cell Research & Therapy · 2015
    6. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    7. Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing PLoS ONE · 2013
    8. Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes ˜The œAmerican journal of pathology · 2005