The Therapeutic Efficacy of Mesenchymal Stem Cells and Their Extracellular Vesicles in the Treatment of Diverse Skin Diseases

    August 2025 in “ Frontiers in Immunology ”
    Mateusz Matwiejuk, Agnieszka Mikłosz, Hanna Myśliwiec … Iwona Flisiak
    Studysummary This review explores how mesenchymal stem cells and their extracellular vesicles may treat various skin diseases by modulating immune responses and promoting healing, though further clinical trials are needed to confirm their safety and efficacy in practice.
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    Research cited in this study 2

    1. Baricitinib-Loaded EVs Promote Alopecia Areata Mouse Hair Regrowth by Reducing JAK-STAT-Mediated Inflammation and Promoting Hair Follicle Regeneration Drug Discoveries & Therapeutics · 2024
    2. Pimecrolimus Interferes With the Therapeutic Efficacy of Human Mesenchymal Stem Cells in Atopic Dermatitis by Regulating NFAT-COX2 Signaling Stem Cell Research & Therapy · 2021