Exosomes as a Roadmap from Research to Clinical Development in the Management of Skin Diseases

May 2024 in “ Journal of drug delivery science and technology ”

Rutuja Mane, Akash Dhumal, Snehal Shinde, Akhilesh Vardikar, Riyaz Ali M. Osmani, Amarjitsing Rajput

exosomes extracellular vesicle transduction pathways intercellular communication synthetic nanoparticles vitiligo psoriasis systemic lupus erythematosus atopic dermatitis pigment regulation hair growth skin wound regeneration mesenchymal stromal cells tissue engineering regenerative medicine immunomodulation MSCs

TLDR Exosomes show promise for treating skin diseases and improving skin regeneration.

The review explores the potential of exosomes in managing skin diseases, emphasizing their role as therapeutic agents due to their unique molecular makeup and functions. Exosomes can modulate immune responses, aid in tissue regeneration, and offer advantages in drug delivery systems, such as higher bioavailability and reduced side effects. The review also discusses the quality control of exosomes, including stability and purification techniques, and highlights their non-cellular nature, which reduces risks associated with direct cell therapies. Overall, exosomes present a promising avenue for innovative treatments in dermatology.

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Exosomes as a Roadmap from Research to Clinical Development in the Management of Skin Diseases

Research cited in this study

research Stem Cell-Derived Exosomes: Emerging Therapeutic Opportunities for Wound Healing

research Therapeutic Values of Exosomes in Cosmetics, Skin Care, Tissue Regeneration, and Dermatological Diseases

research The Novel Mechanisms and Applications of Exosomes in Dermatology and Cutaneous Medical Aesthetics

research Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by Increasing Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps

research Exosomes for Repair, Regeneration, and Rejuvenation

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