Exosomes as a Roadmap from Research to Clinical Development in the Management of Skin Diseases

May 2024 in “ Journal of drug delivery science and technology ”

Rutuja Mane, Akash Dhumal, Snehal Shinde, Akhilesh Vardikar, Riyaz Ali M. Osmani, Amarjitsing Rajput

exosomes extracellular vesicle transduction pathways intercellular communication synthetic nanoparticles vitiligo psoriasis systemic lupus erythematosus atopic dermatitis pigment regulation hair growth skin wound regeneration mesenchymal stromal cells tissue engineering regenerative medicine immunomodulation MSCs

Studysummary This review highlights the potential of exosomes, particularly those derived from mesenchymal stromal cells, for treating skin conditions and regeneration, but it also identifies challenges in their production and application.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The review explores the potential of exosomes in managing skin diseases, emphasizing their role as therapeutic agents due to their unique molecular makeup and functions. Exosomes can modulate immune responses, aid in tissue regeneration, and offer advantages in drug delivery systems, such as higher bioavailability and reduced side effects. The review also discusses the quality control of exosomes, including stability and purification techniques, and highlights their non-cellular nature, which reduces risks associated with direct cell therapies. Overall, exosomes present a promising avenue for innovative treatments in dermatology.

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