Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata

The study demonstrated that exosomes derived from myeloid-derived suppressor cells (MDSC-Exo) had significant immunoregulatory effects in a mouse model of autoimmune alopecia areata (AA). MDSC-Exo suppressed the autoimmune response, leading to reduced severity of AA and partial hair regrowth. They promoted regulatory T cell expansion, reduced inflammatory cytokines, and decreased the proliferation and cytotoxic activity of activated T cells. The therapeutic effects persisted for up to 16 weeks post-treatment, suggesting MDSC-Exo's potential as a promising therapeutic approach for AA and other autoimmune diseases.