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GlossaryMyeloid-Derived Suppressor Cells (MDSCs)

immune cells from bone marrow that suppress immune responses

Myeloid-Derived Suppressor Cells (MDSCs) are a type of immune cell that originates from bone marrow and has the ability to suppress the body's immune response. They play a significant role in cancer and other diseases by inhibiting the activity of T cells and natural killer cells, which can allow tumors to grow and spread more easily.

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research Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata

45 citations, June 2018 in “Frontiers in immunology”

MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.

research Dermatologic Toxicities Associated with Chronic Gamma-Secretase Inhibitor Treatment for Desmoid Tumor

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Most patients experienced mild to moderate skin problems during a trial for a desmoid tumor treatment.

research Tregs: Where We Are and What Comes Next?

130 citations, November 2017 in “Frontiers in Immunology”

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

research TGFβ and Cancer Metastasis: An Inflammation Link

55 citations, April 2010 in “Cancer and Metastasis Reviews”

TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.

research Roles of Tumor Suppressors in Regulating Tumor-Associated Inflammation

44 citations, September 2014 in “Cell Death & Differentiation”

Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.

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