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GlossaryMyeloid-Derived Suppressor Cells (MDSCs)

immune cells from bone marrow that suppress immune responses

Myeloid-Derived Suppressor Cells (MDSCs) are a type of immune cell that originates from bone marrow and has the ability to suppress the body's immune response. They play a significant role in cancer and other diseases by inhibiting the activity of T cells and natural killer cells, which can allow tumors to grow and spread more easily.

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research Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata

45 citations, June 2018 in “Frontiers in immunology”

MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.

research DC-HIL+ Myeloid-Derived Suppressor Cells Are Elevated in the Peripheral Blood and Lesional Skin of Cutaneous Lupus Patients

April 2018 in “Journal of Investigative Dermatology”

Cutaneous lupus patients have higher levels of certain immune cells in their blood and skin.

research Finasteride Enhances the Generation of Human Myeloid-Derived Suppressor Cells by Up-Regulating the COX2/PGE2 Pathway

10 citations, June 2016 in “PLOS ONE”

research An Interview with Drs. Felix Brockschmidt and Markus Nöthen About the Genetics of Androgenetic Alopecia

September 2009 in “Hair transplant forum international”

research Dermatologic Toxicities Associated with Chronic Gamma-Secretase Inhibitor Treatment for Desmoid Tumor

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Most patients experienced mild to moderate skin problems during a trial for a desmoid tumor treatment.

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