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GlossaryMyeloid-Derived Suppressor Cells (MDSCs)

immune cells from bone marrow that suppress immune responses

Myeloid-Derived Suppressor Cells (MDSCs) are a type of immune cell that originates from bone marrow and has the ability to suppress the body's immune response. They play a significant role in cancer and other diseases by inhibiting the activity of T cells and natural killer cells, which can allow tumors to grow and spread more easily.

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research Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata

45 citations, June 2018 in “Frontiers in immunology”

MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.

research The Importance of Myeloid-Derived Suppressor Cells in Regulating Autoimmune Effector Cells in Chronic Contact Eczema

84 citations, October 2007 in “The Journal of Immunology”

Myeloid-derived suppressor cells help control autoimmune cells and promote hair regrowth in alopecia areata.

research Dermatologic Toxicities Associated with Chronic Gamma-Secretase Inhibitor Treatment for Desmoid Tumor

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Most patients experienced mild to moderate skin problems during a trial for a desmoid tumor treatment.

research Tregs: Where We Are and What Comes Next?

130 citations, November 2017 in “Frontiers in Immunology”

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

research TGFβ and Cancer Metastasis: An Inflammation Link

55 citations, April 2010 in “Cancer and Metastasis Reviews”

TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.

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