Tolerance Induction by Hair-Specific Keratins in Murine Alopecia Areata

    July 2013 in “ Journal of Leukocyte Biology ”
    Ulrike Erb, Pia Freyschmidt‐Paul, Margot Zöller
    Studysummary The study suggests that vaccination with soluble keratin peptides K71 and K31 significantly delayed the onset and progression of autoimmune alopecia areata in mice by inducing T cell anergy.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on academic.oup.com →
    Discuss this study in the Community →

    Research cited in this study 30

    1. Genetic Basis of Alopecia Areata Dermatologic clinics · 2012
    2. Alopecia Areata as a Model for T Cell-Dependent Autoimmune Diseases Experimental Dermatology · 2012
    3. Treatment Options for Alopecia: An Update, Looking to the Future Expert Opinion on Pharmacotherapy · 2012
    4. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    5. Advances in the Management of Alopecia Areata The Journal of Dermatology · 2011
    6. Delayed type hypersensitivity‐induced myeloid‐derived suppressor cells regulate autoreactive T cells European Journal of Immunology · 2011
    7. Concurrence of Alopecia Areata and Vitiligo at the Same Anatomical Site Australasian Journal of Dermatology · 2011
    8. The Genetics of Alopecia Areata: What's New and How Will It Help Our Patients? Dermatologic therapy · 2011
    9. The Cell Biology of Human Hair Follicle Pigmentation Pigment cell & melanoma research · 2010
    10. Trichohyalin Is a Potential Major Autoantigen in Human Alopecia Areata Journal of Proteome Research · 2010
    11. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    12. Alopecia Areata Update Journal of the American Academy of Dermatology · 2010
    13. Treatment Strategies for Alopecia Expert Opinion on Pharmacotherapy · 2009
    14. Interventions for Alopecia Areata Journal of Evidence-Based Medicine · 2009
    15. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    16. Angiogenin Is Expressed in Human Dermal Papilla Cells and Stimulates Hair Growth Archives of dermatological research · 2008
    17. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    18. Interventions for Alopecia Areata Cochrane library · 2008
    19. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    20. The Importance of Myeloid-Derived Suppressor Cells in Regulating Autoimmune Effector Cells in Chronic Contact Eczema The Journal of Immunology · 2007
    21. Alopecia in the United States: Outpatient Utilization and Common Prescribing Patterns Journal of the American Academy of Dermatology · 2007
    22. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    23. Characterization of Hair Follicle Antigens Targeted by the Anti-Hair Follicle Immune Response Journal of Investigative Dermatology Symposium Proceedings · 2003
    24. Alopecia Areata: Treatment of Today and Tomorrow Journal of Investigative Dermatology Symposium Proceedings · 2003
    25. Interleukin-10-Deficient Mice Are Less Susceptible to the Induction of Alopecia Areata Journal of Investigative Dermatology · 2002
    26. A Novel Type II Cytokeratin, mK6irs, Is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath Journal of Investigative Dermatology · 2001
    27. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    28. Experimental Induction of Alopecia Areata-Like Hair Loss in C3H/HeJ Mice Using Full-Thickness Skin Grafts ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    29. Autoantibodies to Hair Follicles in C3H/HeJ Mice With Alopecia Areata-Like Hair Loss Journal of Investigative Dermatology · 1997
    30. Coexpression of Keratins Characteristic of Skin and Hair Differentiation in Nail Cells Journal of Investigative Dermatology · 1993

    Related research 6

    1. Serum Zinc Concentration in Patients With Alopecia Areata Acta dermato-venereologica (Print) · 2023
    2. Characterization and Expression Analysis of the Hair Keratin Associated Protein KAP26.1 British Journal of Dermatology · 2008
    3. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    4. Keratins of the Human Hair Follicle International review of cytology · 2005
    5. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    6. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003