Trichohyalin Is a Potential Major Autoantigen in Human Alopecia Areata

    July 2010 in “ Journal of Proteome Research ”
    Man Ching Leung, Chris W. Sutton, David A. Fenton, Desmond J. Tobin
    Studysummary This study suggests that an immune response to trichohyalin and keratin 16 may contribute to the pathogenesis of alopecia areata.
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    Research cited in this study 12

    1. Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans American journal of human genetics · 2009
    2. Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme During the Hair Growth Cycle: Implications for Growth Control and Hair Follicle Transformations ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    3. Keratin 16 Expression Defines a Subset of Epithelial Cells During Skin Morphogenesis and the Hair Cycle Journal of Investigative Dermatology · 2002
    4. Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans Journal of Investigative Dermatology · 2002
    5. Simple and Rapid Method to Isolate and Culture Follicular Papillae from Human Scalp Hair Follicles Experimental Dermatology · 2002
    6. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002
    7. Alopecia Areata: Diagnosis and Management International Journal of Dermatology · 1999
    8. Autoantibodies to Hair Follicles in C3H/HeJ Mice With Alopecia Areata-Like Hair Loss Journal of Investigative Dermatology · 1997
    9. Existence of Trichohyalin-Keratohyalin Hybrid Granules: Co-Localization of Two Major Intermediate Filament-Associated Proteins in Non-Follicular Epithelia Differentiation · 1994
    10. Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986
    11. Trichohyalin, an Intermediate Filament-Associated Protein of the Hair Follicle ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986
    12. Immunohistochemical and Electron Microscopic Characterization of the Cellular Infiltrate in Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 1984

    Related research 5

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    2. Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2001
    3. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000
    4. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    5. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981