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GlossaryKeratin 16 (K16)

protein providing structural support in skin, hair, and nails

Keratin 16 (K16) is a type of protein found in the skin, hair, and nails that helps provide structural support and resilience. It is particularly important in the body's response to stress or injury, as it is upregulated in conditions like psoriasis and certain types of alopecia, where the skin or hair follicles are damaged.

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research Impaired Follicular Nrf2 Signaling: Potential Early Therapeutic Target in Hidradenitis Suppurativa

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Targeting impaired Nrf2 signaling might help treat hidradenitis suppurativa early on.

research Defining the Complex Epithelia That Comprise the Canine Claw With Molecular Markers of Differentiation

6 citations , October 2009 in “Veterinary Dermatology”

Canine claws have complex structures with different keratin types, similar to hair and nails.

research Biochemical and Immunohistochemical Analyses of Keratin Expression in Basal Cell Carcinoma

37 citations , May 1998 in “Journal of Dermatological Science”

Basal cell carcinoma shows keratin patterns similar to undifferentiated hair follicle cells.

research Peer Review of a Novel Control of Human Keratin Expression: Cannabinoid Receptor 1-Mediated Signaling Down-Regulates the Expression of Keratins K6 and K16 in Human Keratinocytes In Vitro and In Situ

February 2013

Activating CB1 can reduce keratin levels, potentially helping manage psoriasis and aid wound healing.

research CDNA Cloning, Expression, And Assembly Characteristics Of Mouse Keratin 16

32 citations , November 1998 in “Journal of Biological Chemistry”

Mouse and human keratin 16 can both form filaments, with differences likely due to the tail domain, not the helical domain.

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