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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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5 / 1000+ resultsresearch Identification of human hair follicle antigens targeted in the presumptive autoimmune hair follicle disorder alopecia areata and their potential functional relevance in vitro : methods development for isolation and identification of alopecia areata-relevant human hair follicle antigens using a proteomics approach and their functional assessment using an ex vivo hair follicle organ culture model
This study investigated the autoimmune basis of alopecia areata (AA) by identifying hair follicle antigens targeted by antibodies in AA patients. Using serum antibodies from 10 AA patients and 10 controls, researchers identified trichohyalin and keratin 16 as potential target antigens through mass spectrometry. Trichohyalin was immunoprecipitated by all AA sera and only 5 normal sera, with significantly higher Mascot scores in the AA group (p=0.005). Functional studies showed that antibodies to these proteins inhibited hair fibre elongation in ex vivo cultures. Indirect immunofluorescence indicated higher immunoreactivity in AA sera against anagen hair follicles, particularly in the outer and inner root sheaths. The findings suggested an antibody response to anagen-specific hair follicle antigens in AA, potentially playing a pathogenic role.
research Trichohyalin is a Potential Major Autoantigen in Human Alopecia Areata
This study provided evidence supporting the autoimmune basis of alopecia areata (AA) by identifying trichohyalin as a potential major autoantigen involved in its pathogenesis. Using serum antibodies from 10 AA patients, researchers isolated AA-reactive hair follicle-specific antigens and found strong reactivity to trichohyalin, a hair growth phase-specific structural protein, in all AA sera. Keratin 16 (K16) was also identified as another potential target antigen. The findings suggested that an immune response to these anagen-specific hair follicle antigens, particularly trichohyalin and K16, might play a role in the development of AA.
research Autoantigen Discovery in the Hair Loss Disorder, Alopecia Areata: Implications of Post-Translational Modifications
New protein changes may be involved in the immune attack on hair follicles in alopecia areata.
research Immune Niches for Hair Follicle Development and Homeostasis
Immune cells are crucial for hair growth and preventing hair loss.
research The TFIID Subunit TAF4 Regulates Keratinocyte Proliferation and Has Cell-Autonomous and Non-Cell-Autonomous Tumor Suppressor Activity in Mouse Epidermis
TAF4 is important for skin cell growth and helps prevent skin cancer in mice.
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5 / 398 resultscommunity Summary of Procapil video by Haircafe
Procapil is marketed as a natural hair loss treatment but lacks strong evidence and is industry-biased. Minoxidil and Finasteride are the only FDA-approved treatments for androgenetic alopecia.
community Weed/THC effects on hair growth/hair loss, and vitality of organ-culture human follicle studies (research review)
Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hair follicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.
community Solving Hair Loss with Research at MIT
Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.
community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System
PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.
community Predict if You'll Shed and Responding to Treatment: Ultrasound Imaging Technology
Ultrasound imaging can predict hair shedding and assess hair growth stages by analyzing hair follicle characteristics. The conversation also discusses using ultrasound for personal hair analysis and mentions the potential use of infrared emission for hair treatment.