The TFIID Subunit TAF4 Regulates Keratinocyte Proliferation and Has Cell-Autonomous and Non-Cell-Autonomous Tumor Suppressor Activity in Mouse Epidermis

    July 2007 in “ Development ”
    Anas Fadloun, Dominique Kobi, Jean-Christophe Pointud … Irwin Davidson
    Studysummary In this study, inactivating the TAF4 subunit of transcription factor TFIID in mouse epidermis disrupted gene expression linked to skin and hair function, and increased tumor risk.
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    Research cited in this study 7

    1. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006
    2. Epidermal Differentiation: The Role of Proteases and Their Inhibitors European Journal of Cell Biology · 2004
    3. Epimorphin Acts to Induce Hair Follicle Anagen in C57BL/6 Mice The FASEB Journal · 2003
    4. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002
    5. Physiological and Retinoid-Induced Proliferations of Epidermis Basal Keratinocytes Are Differently Controlled EMBO journal · 2002
    6. Skin Abnormalities Generated by Temporally Controlled RXRα Mutations in Mouse Epidermis Nature · 2000
    7. Epidermal Dysplasia and Abnormal Hair Follicles in Transgenic Mice Overexpressing Homeobox Gene MSX-2 Journal of Investigative Dermatology · 1999

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