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Glossary Papillomas

benign skin growths caused by human papillomavirus (HPV)

Papillomas, also known as warts or verrucae, are benign (non-cancerous) growths caused by the human papillomavirus (HPV). They typically appear as small, rough, raised lesions on the skin or mucous membranes and can occur anywhere on the body. While generally harmless, they can sometimes cause discomfort or be cosmetically concerning, and in rare cases, certain types of HPV can lead to more serious conditions.

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research Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10.

33 citations , March 1994 in “PubMed”

This study reported that high ornithine decarboxylase expression and decreased keratin K1 and K10 expression may serve as useful markers for early stages of tumor development in mouse skin.

research Inhibition of CCAAT/Enhancer Binding Protein Family DNA Binding in Mouse Epidermis Prevents and Regresses Papillomas

28 citations , February 2007 in “Cancer Research”

This study found that inhibiting C/EBP transcription factors in mouse skin reduced papilloma formation and caused systemic hair loss, suggesting C/EBP may be a potential therapeutic target.

research Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.

99 citations , February 2000 in “PubMed”

This study found that overexpression of PKCepsilon in transgenic mice reduced papilloma development but accelerated carcinoma formation in a skin tumor promotion model.

research A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse

44 citations , March 2012 in “Molecular Carcinogenesis”

This study found that keratin 15 expressing cells from the hair follicle contribute to the development and long-term persistence of cutaneous papillomas in transgenic mice, with a subset showing the Ha-ras mutation.

research The Human Papillomavirus Type 11 Upstream Regulatory Region Triggers Hair-Follicle-Specific Gene Expression in Transgenic Mice

9 citations , June 1999 in “Journal of Investigative Dermatology”

This study observed hair-specific transcription of a reporter gene in transgenic mice, with increased expression after dexamethasone and ultraviolet B treatment.

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