The Genetics of Alopecia Areata: What's New and How Will It Help Our Patients?

    May 2011 in “ Dermatologic therapy ”
    Lynn Petukhova, Rita Cabral, Julian Mackay‐Wiggan, Raphael Clynes, Angela M. Christiano
    TLDR New genetic discoveries in alopecia areata could lead to better treatments.
    Alopecia areata (AA) was identified as the most prevalent autoimmune disease in the United States, affecting approximately 5.3 million people. Despite its high prevalence, there was limited information on its pathogenesis and no evidence-based treatments. A genome-wide association study (GWAS) identified at least eight genomic regions associated with AA, highlighting specific genes linked to other autoimmune diseases with existing or developing targeted therapies. These genetic insights paved the way for developing novel therapeutic approaches and marked the beginning of translational research in AA based on genetic findings.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 1000+ results

      community C’est terrible - at my wits end

      in Female  450 upvotes 2 years ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Hairloss all over body and head

      in Treatment  2 upvotes 2 months ago
      A 25-year-old experiencing hair thinning all over the body and head, despite using minoxidil and having low vitamin D levels, is advised to seek a second opinion from a dermatologist specializing in hair loss. The likely diagnosis is diffuse alopecia areata, which may require treatment with a JAK inhibitor.

      community Fuck hair loss; acquire beard.

      in Shaved/buzzed  929 upvotes 3 years ago
      A user's transformation from an accountant to a spartan with a full beard, discussing the potential of DUPA and alopecia areata, as well as treatments like vitamins, topicals, and natural treatments for potential regrowth.

      community Rare Non responder to Finasteride, Dutasteride, and oral minoxidil

      in Minoxidil  78 upvotes 2 years ago
      A user did not respond to finasteride, dutasteride, and oral minoxidil for hair loss after four years of treatment and is considering scalp micropigmentation (SMP). Other users suggest the hair loss pattern may indicate alopecia areata and recommend seeing a dermatologist.

    Similar Research

    5 / 1000+ results