The Genetic Architecture of Alopecia Areata

    December 2013 in “ Journal of Investigative Dermatology Symposium Proceedings ”
    Lynn Petukhova, Angela M. Christiano
    TLDR Genetic discoveries are leading to new treatments for alopecia areata.
    The document reviewed the genetic basis of alopecia areata (AA), highlighting significant progress through genome-wide association studies (GWAS) and other genetic research methods. It identified several genomic regions and specific genes, such as CTLA4, IL-2/IL-21, and STX17, linked to AA, implicating both common and rare risk alleles. The study involved 38 families and compared 1,054 AA patients with 3,278 controls, finding that AA shares genetic risk factors with other autoimmune diseases. The findings suggested potential therapeutic targets, including drugs like Abatacept, and emphasized the importance of continued genetic research and larger sample sizes to develop effective treatments and precision medicine for AA.
    Discuss this study in the Community →

    Research cited in this study

    10 / 10 results

    Related Community Posts Join

    6 / 1000+ results

      community C’est terrible - at my wits end

      in Female  450 upvotes 2 years ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community find a cure for this shit already

      in Chat  208 upvotes 5 years ago
      Treatments used to prevent and treat male pattern baldness, the difficulty in finding a permanent cure for hair loss, and the potential financial motivations of companies not wanting to find a cure.

      community Well here I am 3-4 years later.

      in Update  56 upvotes 2 years ago
      The conversation is about someone who has been taking finasteride for hair loss without success, considering switching to dutasteride or giving up treatment. Suggestions include trying dutasteride, microneedling, infrared therapy, multivitamins, and high-concentration topical solutions combining finasteride and dutasteride.

    Related Research

    1 / 1 results