Alopecia Areata Is Associated With MICA and an Extended HLA Haplotype

    March 2004 in “ Journal of the American Academy of Dermatology ”
    Nazila Barahmani, Mariza de Andrade, Joshua P. Slusser, Madeleine Duvic
    Image of study
    TLDR Certain genes are linked to the risk of developing Alopecia Areata.
    In a study from 2004, researchers investigated the genetic associations of Alopecia Areata (AA), an autoimmune disease targeting hair follicles, with specific alleles in the human major histocompatibility complex (MHC) region on chromosome 6.p21. They examined polymorphic alleles of 10 microsatellite markers in 10 large multiplex families using polymerase chain reaction and genotyping. The study found an association between the MICA locus and AA with a p-value of 0.012. However, no association was found between the other nine markers and AA in these families. Further analysis in a larger sample of 94 families revealed a strong association between the haplotype MICA*3-DR*6-DQ6 and AA, with a p-value of 0.00093, suggesting a genetic susceptibility linked to this specific haplotype.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 4 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 1 year ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

    Similar Research

    5 / 1000+ results