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GlossaryMICA

protein involved in immune response and stress detection

MICA stands for MHC class I polypeptide-related sequence A. It is a protein that is part of the immune system and is involved in the body's response to stress and infection. MICA is expressed on the surface of certain cells and can be recognized by natural killer (NK) cells, which play a role in targeting and destroying infected or cancerous cells. In the context of hair and alopecia, variations in the MICA gene have been studied for their potential association with autoimmune conditions like alopecia areata.

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research Updates in the Pathogenesis of Alopecia Areata

April 2021 in “Sohag Medical Journal”

Alopecia areata is an autoimmune condition causing hair loss, linked to genetic factors and immune system issues, with no cure yet.

research Dandruff Lesional Scalp Skin Exhibits Epidermal T Cell Infiltration and a Weakened Hair Follicle Immune Privilege

March 2024 in “International Journal of Cosmetic Science”

Dandruff is linked to increased T cells and weakened immune protection in hair follicles.

research Environmental Pathobiology of Frontal Fibrosing Alopecia: Does Linalool Promote FFA Development and Progression?

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Linalool in personal care products may contribute to hair loss by damaging hair follicle stem cells and triggering harmful immune responses.

research Vδ1+ T-Cells Are Stress-Sentinels in Human Skin and Are Implicated in Alopecia Areata Pathogenesis

1 citations , August 2016 in “Journal of Investigative Dermatology”

Vδ1+ T-cells in the skin contribute to hair loss in alopecia areata and could be targeted for treatment.

research The PDE4 Inhibitor, Apremilast, Suppresses Experimentally Induced Alopecia Areata in Human Skin In Vivo

52 citations , December 2014 in “Journal of Dermatological Science”

Apremilast may help treat hair loss in alopecia areata.

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