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GlossaryMicrophthalmia-associated transcription factor

regulates genes for pigment production in skin, hair, and eyes

Microphthalmia-associated transcription factor (MITF) is a protein that plays a crucial role in the development and function of various cell types, including melanocytes, which are responsible for producing the pigment melanin in the skin, hair, and eyes. It regulates the expression of genes involved in cell growth, differentiation, and survival, and mutations in the MITF gene can lead to conditions like Waardenburg syndrome and certain types of albinism.

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research Melanogenesis-Promoting Effect of Cirsium Japonicum Flower Extract In Vitro and Ex Vivo

4 citations , October 2021 in “International Journal of Cosmetic Science”

Cirsium japonicum flower extract increases melanin production and could help treat depigmentation conditions.

research Tribuloside Acts on the PDE/cAMP/PKA Pathway to Enhance Melanogenesis, Melanocyte Dendricity and Melanosome Transport

December 2023 in “Journal of ethnopharmacology”

Tribuloside can increase skin pigmentation by enhancing melanin production and distribution.

research The Peripheral Clock Regulates Human Pigmentation

81 citations , October 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

Certain genes control the color of human hair by affecting pigment production.

research Melanocytes and Vitiligo and Hair Graying

1 citations , January 2014 in “Elsevier eBooks”

Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.

Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

research Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

July 2023

The human scalp has different types of pigment cells in hair follicles with varying abilities to produce pigment.

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