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GlossaryMicrophthalmia-associated transcription factor

regulates genes for pigment production in skin, hair, and eyes

Microphthalmia-associated transcription factor (MITF) is a protein that plays a crucial role in the development and function of various cell types, including melanocytes, which are responsible for producing the pigment melanin in the skin, hair, and eyes. It regulates the expression of genes involved in cell growth, differentiation, and survival, and mutations in the MITF gene can lead to conditions like Waardenburg syndrome and certain types of albinism.

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research The Peripheral Clock Regulates Human Pigmentation

81 citations, April 2015 in “The journal of investigative dermatology/Journal of investigative dermatology”

Certain genes control the color of human hair by affecting pigment production.

research Pigmentation Effect of Rice Bran Extract in Hair Follicle-Like Tissue and Organ Culture Models

6 citations, October 2019 in “Jo'jig gonghag gwa jaesaeng uihag/Tissue engineering and regenerative medicine”

Rice bran extract boosts melanin production in hair follicles.

research Melanocytes and Vitiligo and Hair Graying

1 citations, January 2014 in “Elsevier eBooks”

Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.

research Tribuloside Acts on the PDE/cAMP/PKA Pathway to Enhance Melanogenesis, Melanocyte Dendricity and Melanosome Transport

April 2024 in “Journal of ethnopharmacology”

Tribuloside can increase skin pigmentation by enhancing melanin production and distribution.

research Differentiation of CD34+ Human Hair Follicle Stem Cells into Functional Melanocytes

1 citations, December 2018 in “IOP conference series. Materials science and engineering”

CD34+ hair follicle stem cells can become melanin-producing cells for treating skin conditions.

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