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    Glossary Microphthalmia-associated transcription factor

    regulates genes for pigment production in skin, hair, and eyes

    Microphthalmia-associated transcription factor (MITF) is a protein that plays a crucial role in the development and function of various cell types, including melanocytes, which are responsible for producing the pigment melanin in the skin, hair, and eyes. It regulates the expression of genes involved in cell growth, differentiation, and survival, and mutations in the MITF gene can lead to conditions like Waardenburg syndrome and certain types of albinism.

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    Research 30 of 299

    1. The Suppression Effects of Fat Mass and Obesity Associated Gene on the Hair Follicle-Derived Neural Crest Stem Cells Differentiating into Melanocyte by N6-Methyladenosine Modifying Microphthalmia-Associated Transcription Factor International Journal of Stem Cells · 2023 · 4 citations
    2. Microphthalmic-associated transcription factor integrates melanocyte biology and melanoma progression. Clinical Cancer Research · 2006 · 21 citations
    3. Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor Journal of Ginseng Research · 2015 · 33 citations
    4. The Peripheral Clock Regulates Human Pigmentation 2014 · 81 citations
    5. Optimization of the method for the culture of melanocyte precursors from hair follicles and their activation by 1,25-dihydroxyvitamin D3 Experimental and Therapeutic Medicine · 2013 · 7 citations
    6. Pigmentation Effect of Rice Bran Extract in Hair Follicle-Like Tissue and Organ Culture Models 2019 · 6 citations
    7. Lipid‐mediated signalling and melanocyte function Pigment Cell & Melanoma Research · 2009 · 6 citations
    8. Melanogenesis‐promoting effect of <i>Cirsium japonicum</i> flower extract in vitro and ex vivo International Journal of Cosmetic Science · 2021 · 4 citations
    9. Melanocytes and Vitiligo (and Hair Graying) Elsevier eBooks · 2014 · 1 citations
    10. Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport Journal of ethnopharmacology · 2023
    11. Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity 2023
    12. Sulfated hyaluronan‐containing artificial extracellular matrices promote proliferation of keratinocytes and melanotic phenotype of melanocytes from the outer root sheath of hair follicles Journal of Biomedical Materials Research Part A · 2019 · 8 citations
    13. Differentiation of CD34+ Human Hair Follicle Stem Cells into Functional Melanocytes IOP conference series. Materials science and engineering · 2018 · 1 citations
    14. LHX2: a transcription factor in development, homeostasis, repair, and disease Frontiers in Cell and Developmental Biology · 2026
    15. Intrinsic and Extrinsic Factors Associated with Hair Graying (Canities) and Therapeutic Potential of Plant Extracts and Phytochemicals Applied Sciences · 2024
    16. LB999 Role of transcription factor Ovol2 in skin epithelial regeneration and repair Journal of Investigative Dermatology · 2017
    17. The complex relationship between TFEB transcription factor phosphorylation and subcellular localization EMBO journal · 2018 · 344 citations
    18. Post-transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation and Hair Follicle Regression by miR-22 PLOS Genetics · 2015 · 52 citations
    19. Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer Animals · 2023
    20. ATP-dependent chromatin remodeling during mammalian development Development · 2016 · 182 citations
    21. Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles American Journal Of Pathology · 2006 · 344 citations
    22. Fundamental hair follicle biology and fine fibre production in animals animal · 2010 · 170 citations
    23. Coloration in Equine: Overview of Candidate Genes Associated with Coat Color Phenotypes Animals · 2024 · 4 citations
    24. Role of Metformin in Acanthosis Nigricans International Journal of Dermatology Venereology and Leprosy Sciences · 2026
    25. Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis 2013 · 29 citations
    26. Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors Nature Communications · 2014 · 66 citations
    27. Involvement of hair follicles in skin tumorigenesis, skin homeostasis and wound healing Medical Research Archives · 2025
    28. Editor's evaluation: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis 2022
    29. Segmental Vitiligo Springer eBooks · 2019 · 2 citations
    30. SOX2 in the Skin Elsevier eBooks · 2015 · 1 citations