Tribuloside Acts on the PDE/cAMP/PKA Pathway to Enhance Melanogenesis, Melanocyte Dendricity and Melanosome Transport
December 2023
in “
Journal of ethnopharmacology
”
tribuloside phosphodiesterase cyclic adenosine monophosphate cAMP protein kinase A PKA cAMP-response element binding CREB microphthalmia-associated transcription factor MITF tyrosinase tyrosinase-related protein-1 TRP-1 tyrosinase-related protein-2 TRP-2 Rab27a cell division cycle protein 42 Cdc42 melanogenesis melanocyte dendricity melanin transport Tribulus terrestris PDE
Studysummary This study found that tribuloside, a flavonoid from Tribulus terrestris L., enhances melanin production in human melanocytes, zebrafish, and human skin samples without causing toxicity, potentially through inhibiting PDE to increase cAMP levels and promote the melanin biosynthesis pathway.
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