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GlossaryPhosphodiesterase

enzyme that breaks down cyclic nucleotides in cells

Phosphodiesterase (PDE) is an enzyme that plays a crucial role in cellular signaling by breaking down cyclic nucleotides like cAMP and cGMP, which are molecules that transmit signals inside cells. By regulating the levels of these cyclic nucleotides, PDEs help control various physiological processes, including heart rate, inflammation, and even hair growth.

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learn Caffeine

the stimulant you know and love can be used topically to stimulate hair

Research

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research Caffeine’s Mechanisms of Action and Its Cosmetic Use

153 citations , October 2012 in “Skin Pharmacology and Physiology”

Caffeine in cosmetics may reduce cellulite, protect skin, and stimulate hair growth, but more research is needed on its use and effects.

research Role of Caffeine in the Management of Androgenetic Alopecia

11 citations , July 2012 in “International Journal of Trichology”

Caffeine may help hair growth in hereditary hair loss.

research Tribuloside Acts on the PDE/cAMP/PKA Pathway to Enhance Melanogenesis, Melanocyte Dendricity and Melanosome Transport

December 2023 in “Journal of ethnopharmacology”

Tribuloside can increase skin pigmentation by enhancing melanin production and distribution.

research Caffeine and Its Role in Regulating Androgenetic Alopecia

February 2021

Caffeine can potentially treat common hair loss by counteracting hair follicle shrinkage caused by hormones.

research Most Recent Findings of Curative Drugs for Lower Urinary Tract Symptoms in Clinical Practice

January 2019 in “Nihon Yakuri Gakkai nenkai yoshishu”

Current treatments for lower urinary tract symptoms include α1-blockers, 5ARIs, PDE5 inhibitors, anticholinergic agents, and β3-adrenergic receptor agonists.

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community I’m so happy (5% topical min daily + 1mg fin daily – no sides)

in Progress Pictures 481 upvotes 4 years ago

User happy with 5% topical minoxidil and 1mg finasteride daily, no side effects. Noticed improvement after 3 months, including hairline and crown.

community Cardio for more than 60 minutes reduces DHT levels and improve hair growth

in Research/Science 126 upvotes 1 year ago

Long aerobic exercise (over 60 minutes) can reduce DHT levels and improve hair health. Some users discuss using Tadalafil (Cialis) to further reduce DHT after exercise, while others mention using treatments like Minoxidil, Finasteride, and RU58841 for hair growth.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

MagicBold in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.