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GlossaryPhosphodiesterase

enzyme that breaks down cyclic nucleotides in cells

Phosphodiesterase (PDE) is an enzyme that plays a crucial role in cellular signaling by breaking down cyclic nucleotides like cAMP and cGMP, which are molecules that transmit signals inside cells. By regulating the levels of these cyclic nucleotides, PDEs help control various physiological processes, including heart rate, inflammation, and even hair growth.

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learn Caffeine

the stimulant you know and love can be used topically to stimulate hair

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research The Effect of Cilostazol, a Phosphodiesterase 3 (PDE3) Inhibitor, on Human Hair Growth with Dual Promoting Mechanisms

21 citations, April 2018 in “Journal of Dermatological Science”

Cilostazol helps hair grow by making hair root cells grow faster and changing growth factor levels.

Systematic Review of Newer Agents for the Management of Alopecia Areata in Adults: Janus Kinase Inhibitors, Biologics and Phosphodiesterase-4 Inhibitors

research Systematic Review of Newer Agents for the Management of Alopecia Areata in Adults: Janus Kinase Inhibitors, Biologics and Phosphodiesterase-4 Inhibitors

12 citations, December 2022 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

New oral treatments for adult hair loss show promise, especially JAK inhibitors, with mild side effects.

research Phosphodiesterase Inhibitors and Prostaglandin Analogues in Dermatology: A Comprehensive Review

9 citations, December 2020 in “Dermatologic Therapy”

Certain drugs are effective for skin conditions like psoriasis, vitiligo, and hair loss.

research The Use of Phosphodiesterase Inhibitors for the Treatment of Alopecia

3 citations, April 2019 in “Journal of Dermatological Treatment”

Caffeine shows promise for treating some types of hair loss, but more research is needed.

research Comment on ‘Androgenetic Alopecia Is Associated with Increased Scalp Hardness’: Role of Phosphodiesterase Inhibitors?

1 citations, April 2020 in “Journal of The European Academy of Dermatology and Venereology”

Drugs like PDEI may help hair disorders like AGA.

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