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GlossaryApremilast

medication for inflammatory conditions, inhibiting enzyme PDE4 to reduce inflammation

Apremilast is a medication used to treat certain inflammatory conditions like psoriasis and psoriatic arthritis. It works by inhibiting an enzyme called phosphodiesterase 4 (PDE4), which helps reduce inflammation in the body.

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Systematic Review of Newer Agents for the Management of Alopecia Areata in Adults: Janus Kinase Inhibitors, Biologics and Phosphodiesterase-4 Inhibitors

research Systematic Review of Newer Agents for the Management of Alopecia Areata in Adults: Janus Kinase Inhibitors, Biologics and Phosphodiesterase-4 Inhibitors

12 citations , December 2022 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

New oral treatments for adult hair loss show promise, especially JAK inhibitors, with mild side effects.

The Relative Efficacy of Monotherapy With Janus Kinase Inhibitors, Dupilumab and Apremilast in Adults With Alopecia Areata: Network Meta-Analyses of Clinical Trials

research The Relative Efficacy of Monotherapy With Janus Kinase Inhibitors, Dupilumab and Apremilast in Adults With Alopecia Areata: Network Meta-Analyses of Clinical Trials

2 citations , July 2023 in “Journal of cosmetic dermatology”

JAK inhibitors are more effective and safer for treating alopecia areata than dupilumab and apremilast.

research Comment on ‘Androgenetic Alopecia Is Associated with Increased Scalp Hardness’: Role of Phosphodiesterase Inhibitors?

1 citations , April 2020 in “Journal of The European Academy of Dermatology and Venereology”

Drugs like PDEI may help hair disorders like AGA.

research The Use of Phosphodiesterase Inhibitors for the Treatment of Alopecia

3 citations , April 2019 in “Journal of Dermatological Treatment”

Caffeine shows promise for treating some types of hair loss, but more research is needed.

research Efficacy of Oral Apremilast in the Treatment of Alopecia Areata at the Tertiary Care Hospital, Karachi

December 2023 in “Journal of health and rehabilitation research”

Oral Apremilast effectively treats alopecia areata in most patients.

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community Hair Loss “Cure” for Inflammation: Topical Roflumilast

in Research/Science 32 upvotes 2 months ago

Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 52 upvotes 1 year ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community 2020 Hair and Scalp Treatments: A Clinical Guide (in Depth 350 Page Guide)

in Treatment 64 upvotes 6 years ago

Treatments for hair loss, including topical immunotherapy, regenerative treatments, laser and light-based therapies, oral supplements, intralesional steroids, and new drugs like finasteride and minoxidil.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 412 upvotes 11 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.