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    Glossary PDE4 inhibitors

    block an enzyme to reduce inflammation and immune responses

    PDE4 inhibitors, also known as Phosphodiesterase 4 inhibitors or PDE4i, are a class of drugs that block the enzyme phosphodiesterase 4. This enzyme is involved in breaking down cyclic adenosine monophosphate (cAMP), a molecule that plays a crucial role in regulating inflammation and immune responses. By inhibiting PDE4, these drugs can help reduce inflammation and are used to treat conditions like psoriasis, chronic obstructive pulmonary disease (COPD), and certain types of alopecia.

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    Research 10 of 117

    1. The PDE4 inhibitor, apremilast, suppresses experimentally induced alopecia areata in human skin in vivo Journal of Dermatological Science · 2014 · 52 citations
    2. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis Journal of Advanced Research · 2024 · 8 citations
    3. The relative efficacy of monotherapy with Janus kinase inhibitors, dupilumab and apremilast in adults with alopecia areata: Network meta‐analyses of clinical trials Journal of cosmetic dermatology · 2023 · 2 citations
    4. Phosphodiesterase (PDE) Inhibitors for the Treatment of Inflammatory Skin Conditions Springer eBooks · 2018
    5. Systematic review of newer agents for the management of alopecia areata in adults: Janus kinase inhibitors, biologics and phosphodiesterase‐4 inhibitors 2022 · 12 citations
    6. Alopecia areata Journal of the American Academy of Dermatology · 2017 · 182 citations
    7. Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies Autoimmunity reviews · 2016 · 82 citations
    8. The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm Advances in Therapy · 2017 · 77 citations
    9. A novel therapeutic paradigm for patients with extensive alopecia areata Expert Opinion on Biological Therapy · 2016 · 30 citations
    10. Seborrheic Dermatitis Revisited: Pathophysiology, Diagnosis, and Emerging Therapies—A Narrative Review Biomedicines · 2025 · 3 citations
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