Search
for

    Glossary PDE4 inhibitors

    block an enzyme to reduce inflammation and immune responses

    PDE4 inhibitors, also known as Phosphodiesterase 4 inhibitors or PDE4i, are a class of drugs that block the enzyme phosphodiesterase 4. This enzyme is involved in breaking down cyclic adenosine monophosphate (cAMP), a molecule that plays a crucial role in regulating inflammation and immune responses. By inhibiting PDE4, these drugs can help reduce inflammation and are used to treat conditions like psoriasis, chronic obstructive pulmonary disease (COPD), and certain types of alopecia.

    Related Terms

    Sort by

    Research 30 of 117

    1. The PDE4 inhibitor, apremilast, suppresses experimentally induced alopecia areata in human skin in vivo Journal of Dermatological Science · 2014 · 52 citations
    2. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis Journal of Advanced Research · 2024 · 8 citations
    3. The relative efficacy of monotherapy with Janus kinase inhibitors, dupilumab and apremilast in adults with alopecia areata: Network meta‐analyses of clinical trials Journal of cosmetic dermatology · 2023 · 2 citations
    4. Phosphodiesterase (PDE) Inhibitors for the Treatment of Inflammatory Skin Conditions Springer eBooks · 2018
    5. Systematic review of newer agents for the management of alopecia areata in adults: Janus kinase inhibitors, biologics and phosphodiesterase‐4 inhibitors 2022 · 12 citations
    6. Alopecia areata Journal of the American Academy of Dermatology · 2017 · 182 citations
    7. Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies Autoimmunity reviews · 2016 · 82 citations
    8. The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm Advances in Therapy · 2017 · 77 citations
    9. A novel therapeutic paradigm for patients with extensive alopecia areata Expert Opinion on Biological Therapy · 2016 · 30 citations
    10. Seborrheic Dermatitis Revisited: Pathophysiology, Diagnosis, and Emerging Therapies—A Narrative Review Biomedicines · 2025 · 3 citations
    11. From mechanisms to therapies: current advances breakthroughs in alopecia areata immunopathology Frontiers in Immunology · 2025 · 3 citations
    12. Alopecia Areata: A Complex Cytokine Driven Disease 2020 · 3 citations
    13. Dupilumab for alopecia areata treatment: A double‐edged sword? Journal of cosmetic dermatology · 2022 · 2 citations
    14. Pyroptosis in Alopecia Areata: Synthesizing Emerging Hypotheses and Charting a Path to New Therapies Biomedicines · 2025
    15. Alopesi Tedavisinde Kullanılan İlaç Tedavileri ve Yeni Yaklaşımlar 2025
    16. A retrospective review of paediatric alopecia areata cases seen in a tertiary institution in Singapore Singapore Medical Journal · 2022
    17. Lack of efficacy of apremilast in 9 patients with severe alopecia areata Journal of the American Academy of Dermatology · 2017 · 23 citations
    18. Apremilast and tofacitinib exert differential effects in the humanized mouse model of alopecia areata British Journal of Dermatology · 2019 · 5 citations
    19. Crisaborole as a Potential Treatment for Pediatric Alopecia Areata: A Case Report and Literature Review Cureus · 2026
    20. 1113 Targeting anti-inflammatory immunonanocarriers to human and murine neutrophils via Ly6 antigen for psoriasiform dermatitis alleviation Journal of Investigative Dermatology · 2023
    21. Apremilast treatment of atopic dermatitis and other chronic eczematous dermatoses Journal of the American Academy of Dermatology · 2017 · 31 citations
    22. A randomized placebo-controlled single-center pilot study of the safety and efficacy of apremilast in subjects with moderate-to-severe alopecia areata Archives of dermatological research · 2018 · 42 citations
    23. Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation Theranostics · 2021 · 18 citations
    24. Exploring the Complexities of Atopic Dermatitis: Pathophysiological Mechanisms and Therapeutic Approaches Journal of Biotechnology and Biomedicine · 2024 · 6 citations
    25. Biologic Therapies and Small-Molecule Inhibitors for Dissecting Cellulitis of the Scalp: A Systematic Review Dermatology and Therapy · 2026
    26. Phosphodiesterase inhibitors and prostaglandin analogues in dermatology: A comprehensive review Dermatologic Therapy · 2020 · 9 citations
    27. The use of phosphodiesterase inhibitors for the treatment of alopecia Journal of Dermatological Treatment · 2019 · 3 citations
    28. 277 An open label pilot clinical trial of the JAK inhibitor tofacitinib for alopecia areata Journal of Investigative Dermatology · 2016 · 3 citations
    29. Comment on ‘Androgenetic alopecia is associated with increased scalp hardness’: role of phosphodiesterase inhibitors? Journal of The European Academy of Dermatology and Venereology · 2020 · 1 citations
    30. Editorial: Exploring innovative therapies for rare inflammatory skin diseases Frontiers in Medicine · 2026