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GlossaryPhosphodiesterase Inhibitors

block enzymes that break down cyclic nucleotides

Phosphodiesterase Inhibitors (PDE Inhibitors or PDEIs) are a class of drugs that block the action of phosphodiesterase enzymes, which are responsible for breaking down cyclic nucleotides like cAMP and cGMP. By inhibiting these enzymes, PDE inhibitors can increase the levels of these cyclic nucleotides, leading to various therapeutic effects such as vasodilation, anti-inflammatory actions, and improved cardiac function. These drugs are used to treat conditions like erectile dysfunction, pulmonary hypertension, and certain types of heart failure.

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learn Caffeine

the stimulant you know and love can be used topically to stimulate hair

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research Comment on ‘Androgenetic Alopecia Is Associated with Increased Scalp Hardness’: Role of Phosphodiesterase Inhibitors?

1 citations , April 2020 in “Journal of The European Academy of Dermatology and Venereology”

Drugs like PDEI may help hair disorders like AGA.

research The Use of Phosphodiesterase Inhibitors for the Treatment of Alopecia

3 citations , April 2019 in “Journal of Dermatological Treatment”

Caffeine shows promise for treating some types of hair loss, but more research is needed.

research Phosphodiesterase Inhibitors and Prostaglandin Analogues in Dermatology: A Comprehensive Review

9 citations , December 2020 in “Dermatologic Therapy”

Certain drugs are effective for skin conditions like psoriasis, vitiligo, and hair loss.

research Phosphodiesterase (PDE) Inhibitors for the Treatment of Inflammatory Skin Conditions

January 2018 in “Springer eBooks”

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

research Adverse Effects of Common Medications on Male Fertility

77 citations , June 2015 in “Nature Reviews Urology”

Some common medications can harm male fertility, but many effects can be reversed.

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community I’m so happy (5% topical min daily + 1mg fin daily – no sides)

in Progress Pictures 481 upvotes 4 years ago

User happy with 5% topical minoxidil and 1mg finasteride daily, no side effects. Noticed improvement after 3 months, including hairline and crown.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

MagicBold in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Cardio for more than 60 minutes reduces DHT levels and improve hair growth

in Research/Science 126 upvotes 1 year ago

Long aerobic exercise (over 60 minutes) can reduce DHT levels and improve hair health. Some users discuss using Tadalafil (Cialis) to further reduce DHT after exercise, while others mention using treatments like Minoxidil, Finasteride, and RU58841 for hair growth.