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GlossaryMicrophthalmia-associated transcription factor (MITF)

regulates genes for pigment production in skin, hair, and eyes

Microphthalmia-associated transcription factor (MITF) is a protein that plays a crucial role in the development and function of various cell types, including melanocytes, which are responsible for producing the pigment melanin in the skin, hair, and eyes. It regulates the expression of genes involved in cell growth, differentiation, and survival, and mutations in the MITF gene can lead to conditions like Waardenburg syndrome and certain types of albinism.

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Expression Patterns of MITF During Human Cutaneous Embryogenesis: Evidence for Bulge Epithelial Expression and Persistence of Dermal Melanoblasts

research Expression Patterns of MITF During Human Cutaneous Embryogenesis: Evidence for Bulge Epithelial Expression and Persistence of Dermal Melanoblasts

43 citations , February 2008 in “Journal of cutaneous pathology”

Melanocyte precursors in human fetal skin follow a specific migration pattern and some remain in the skin's deeper layers.

research Retinoids Modulate MITF: A Novel Mechanism in the Regulation of Melanogenesis

January 2015

Retinoids or their analogs could treat skin pigmentation disorders like melasma and vitiligo.

research Retinoids Modulate MITF: A Novel Mechanism in the Regulation of Melanogenesis

January 2015

Retinoids can help treat skin pigmentation disorders by affecting melanin production.

research Genotype-Phenotype Correlations in Cutaneous Melanoma Patients Carrier of the MITF p.E318K Pathogenic Variant

May 2019 in “CINECA IRIS Institutial Research Information System (University of Genoa)”

MITF+ melanoma patients are more likely to have multiple melanomas and unique skin patterns.

research Anti-Graying Effect of the Extract of Pueraria Thunbergiana via Upregulation of cAMP/MITF-M Signaling Pathway

15 citations , August 2014 in “Journal of dermatological science”

Pueraria thunbergiana extract may help prevent hair from turning gray.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.