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GlossaryMicrophthalmia-associated transcription factor (MITF)

regulates genes for pigment production in skin, hair, and eyes

Microphthalmia-associated transcription factor (MITF) is a protein that plays a crucial role in the development and function of various cell types, including melanocytes, which are responsible for producing the pigment melanin in the skin, hair, and eyes. It regulates the expression of genes involved in cell growth, differentiation, and survival, and mutations in the MITF gene can lead to conditions like Waardenburg syndrome and certain types of albinism.

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Expression Patterns of MITF During Human Cutaneous Embryogenesis: Evidence for Bulge Epithelial Expression and Persistence of Dermal Melanoblasts

research Expression Patterns of MITF During Human Cutaneous Embryogenesis: Evidence for Bulge Epithelial Expression and Persistence of Dermal Melanoblasts

43 citations, February 2008 in “Journal of cutaneous pathology”

Melanocyte precursors in human fetal skin follow a specific migration pattern and some remain in the skin's deeper layers.

research Melanocyte Stem Cell Maintenance and Hair Graying

105 citations, April 2005 in “Cell”

Hair graying happens because certain cells aren't maintained properly.

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