Biocompatible Exosomes Derived From Pinctada Martensii Mucus For Therapeutic Melanin Regulation Via α-MSH/NF-κB/MITF Pathway

The study explores the potential of exosomes derived from Pinctada martensii mucus (PMMEXOs) in regulating melanin production, offering a novel approach to treating pigmentation disorders. PMMEXOs were shown to effectively inhibit melanin synthesis in B16-F10 melanoma cells and zebrafish models by activating the NF-κB signaling pathway, which modulates the expression of MITF and its downstream targets, leading to reduced melanin content and tyrosinase activity. The research highlights the biocompatibility of PMMEXOs and their potential as a non-invasive therapeutic strategy for conditions like melasma and age spots, although further investigation is needed to fully understand the specific miRNAs involved and their mechanisms of action.