Biocompatible Exosomes Derived From Pinctada Martensii Mucus For Therapeutic Melanin Regulation Via α-MSH/NF-κB/MITF Pathway

    January 2025 in “ Regenerative Biomaterials ”
    Dandan Mo, Weihao Zheng, Zixin Gao, Ke Ma, Yang Ke, Tao Zeng, Caipeng Qin, Yan Luo, Li Zheng, Sheng Xu
    TLDR Exosomes from Pinctada martensii mucus can safely reduce melanin production, offering a new treatment for skin pigment issues.
    This study explores the use of exosomes derived from Pinctada martensii mucus (PMMEXOs) as a novel treatment for pigmentary disorders by regulating melanin production. PMMEXOs were shown to effectively inhibit melanin synthesis in B16-F10 melanoma cells and zebrafish, with excellent biocompatibility and fewer side effects compared to current treatments. The study identified 556 differentially expressed genes and highlighted the NF-κB signaling pathway's role in melanogenesis regulation. PMMEXOs reduced tyrosinase activity and melanin content by downregulating key melanogenesis-related genes and proteins. Additionally, specific miRNAs in PMMEXOs were found to modulate the NF-κB pathway, supporting their role in melanin inhibition. These findings suggest PMMEXOs as a promising therapeutic strategy for treating pigmentary disorders like melasma and age spots.
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