Exosomes Derived From Mouse Vibrissa Dermal Papilla Cells Promote Hair Follicle Regeneration During Wound Healing By Activating Wnt/β-Catenin Signaling Pathway

    July 2024 in “ Journal of Nanobiotechnology
    Yuanyuan Shang, Jing Wang, Lixia Zhang, Chunmao Han, Kuo Shen, Kejia Wang, Yan Li, Yue Zhang, Liang Luo, Yanhui Jia, Kai Guo, Weixia Cai, Jian Zhang, Xujie Wang, Hongtao Wang, Dahai Hu
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    TLDR Mouse cell exosomes help hair regrowth and wound healing by activating a specific signaling pathway.
    This study demonstrates that exosomes derived from mouse vibrissa dermal papilla cells (DPC-Exos) significantly promote hair follicle (HF) regeneration and accelerate wound healing by activating the Wnt/β-catenin signaling pathway. DPC-Exos were found to stimulate fibroblast proliferation, migration, and hair-inducing capabilities, leading to HF neogenesis in nude mice when combined with neonatal mouse epidermal cells. Blocking the Wnt pathway reduced these effects, confirming the pathway's role in the process. These findings suggest that DPC-Exos could be a promising therapeutic strategy for regenerative wound healing and hair growth enhancement.
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