Extracellular Vesicles from Hair Follicle-Derived Mesenchymal Stromal Cells: Isolation, Characterization, and Therapeutic Potential for Chronic Wound Healing

April 2022 in “ Stem cell research & therapy ”

Kevin Las Heras, Félix Royo, Clara Garcia‐Vallicrosa, Manoli Igartúa, Edorta Santos‐Vizcaíno, Juan M Falcón-Pérez, Rosa María Hernández

TLDR Hair follicle-derived extracellular vesicles may help heal chronic wounds as effectively as those from adipose tissue.

The study investigates the therapeutic potential of extracellular vesicles (EVs) derived from hair follicle mesenchymal stromal cells (HF-MSCs) for chronic wound healing. Researchers isolated and characterized medium-large EVs (m-lEVs) and small EVs (sEVs) from HF-MSCs and compared them to EVs from adipose tissue-derived MSCs (AT-MSCs). Both HF-EVs and AT-EVs expressed typical MSC-EV markers and increased human dermal fibroblasts (HDFs) proliferation and migration, enhanced angiogenesis in human umbilical vein endothelial cells (HUVECs), and protected HDFs from oxidative stress and cytotoxicity in a hyperglycemic environment. The findings suggest that HF-EVs have comparable regenerative potential to AT-EVs, making them promising candidates for chronic wound treatment.

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