Extracellular Vesicles From 3D Cultured Dermal Papilla Cells Improve Wound Healing Via Krüppel-Like Factor 4/Vascular Endothelial Growth Factor A-Driven Angiogenesis
January 2023
in “
Burns and trauma
”
extracellular vesicles 3D cultured dermal papilla cells dermal papilla cells wound healing Krüppel-like factor 4 vascular endothelial growth factor A angiogenesis human umbilical vein endothelial cells HUVECs full-thickness skin injury proliferation lumen formation migration bioinformatics analysis functional experiments EVs 3D DPCs DPCs KLF4 VEGFA skin injury cell growth blood vessel formation
Studysummary This study found that tdDPC-EVs significantly improved wound healing by enhancing angiogenesis through the KLF4/VEGFA axis, offering advantages over traditional DPC-EVs.
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