Rescuing Key Native Traits in Cultured Dermal Papilla Cells for Human Hair Regeneration

    November 2020 in “ Journal of Advanced Research ”
    Carla M. Abreu, Mariana T. Cerqueira, Rogério P. Pirraco, Luca Gasperini, Rui L. Reis, Alexandra P. Marques
    TLDR Conditioned medium from keratinocytes can improve hair growth potential in cultured dermal papilla cells.
    The study demonstrated that preconditioning human dermal papilla (DP) cells with keratinocyte-conditioned medium (KCs-CM) significantly enhanced their hair-inductive properties, crucial for hair regeneration. Key findings included increased alkaline phosphatase (ALP) activity, reduced expression of α-SMA and versican V1, and improved self-aggregation capacity. KCs-CM also modulated the secretion of hair growth mediators like VEGF and IL-6 while decreasing BMP2 and TGF-β1 levels. In vivo, co-grafting KCs-CM preconditioned DP cells with keratinocytes in mice led to the formation of hair follicle (HF) and sebaceous gland (SG)-like structures in 5 out of 7 animals. This approach showed promise for human hair regeneration, representing the best results achieved with adult human cells to date.
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