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Single Cell Transcriptome Profiling of Human Interfollicular Epidermis Reveals Robust Heterogeneity and Divergent Differentiation Lineages

research Single Cell Transcriptome Profiling of Human Interfollicular Epidermis Reveals Robust Heterogeneity and Divergent Differentiation Lineages

April 2018 in “Journal of Investigative Dermatology”

The human skin's outer layer has more variety in cell types and development paths than previously thought.

research Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice Following Topical Application of Fluocinolone Acetonide

2 citations, November 2007 in “Journal of Investigative Dermatology”

Fluocinolone acetonide slows down hair follicle stem cells but speeds up skin cell growth in mice.

research Basal Keratinocytes Exhibit Age-Related Epigenetic and Transcriptomic Alterations Resulting in an Altered Metabolic Profile

April 2023 in “Journal of Investigative Dermatology”

Aging changes skin cells, leading to different DNA methylation and gene activity, affecting cell metabolism and aging signs.

research Rescuing Key Native Traits in Cultured Dermal Papilla Cells for Human Hair Regeneration

30 citations, November 2020 in “Journal of Advanced Research”

Conditioned medium from keratinocytes can improve hair growth potential in cultured dermal papilla cells.

research Epidermal Keratinocyte Stem Cells: Their Maintenance and Regulation

25 citations, December 1992 in “Seminars in cell biology”

Skin stem cells are maintained by signals from nearby cells and vary in their ability to renew and mature.

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community He used Dutasteride for 20 YEARS: TL;DR Slight gains and largely stable for 20 years.

in Treatment 24 upvotes 8 months ago

John has experienced slight hair gains and stability over 20 years using Dutasteride, which is more effective than Finasteride in reducing scalp DHT and maintaining hair. Dutasteride at 0.5mg daily has a similar side effect profile to Finasteride, but at higher doses, it may increase the risk of sexual side effects.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community does lowering your prolactin levels regrow hair?

in Research/Science 9 upvotes 1 year ago

The potential of lowering prolactin levels to regrow hair, with a reference to Bayer's drug HMI 115 which has been indicated as having this effect. Treatments mentioned include Minoxidil and Finasteride, as well as RU58841.

community Been on dut 0.5mg daily for 12 months. I am cooked.

in Progress Pictures 10 upvotes 3 months ago

A user took finasteride for six months, then switched to dutasteride for a year, increasing the dosage over time, but hair shedding worsened. Replies suggest the issue is male pattern baldness and DHT-related.

community HMI-115: What We Know So Far. HMI-115 (also known as BAY1158061) is a new pharmaceutical drug developed by a biopharmaceutical company called Bioinvent and licensed by Bayer

in Research/Science 51 upvotes 5 months ago

HMI-115 is a new drug developed by Bioinvent and licensed by Bayer, with mixed opinions on its potential effectiveness. Some users are skeptical and prefer proven treatments like Minoxidil, finasteride, and RU58841.

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