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Single Cell Transcriptome Profiling of Human Interfollicular Epidermis Reveals Robust Heterogeneity and Divergent Differentiation Lineages

research Single Cell Transcriptome Profiling of Human Interfollicular Epidermis Reveals Robust Heterogeneity and Divergent Differentiation Lineages

April 2018 in “Journal of Investigative Dermatology”

The human skin's outer layer has more variety in cell types and development paths than previously thought.

research Interfollicular Epidermal Stem-Like Cells for the Recreation of the Hair Follicle Epithelial Compartment

14 citations, January 2021 in “Stem cell research & therapy”

Human skin cells with stem-like features can help create new hair follicles and sebaceous glands when combined with other cells.

research Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice Following Topical Application of Fluocinolone Acetonide

2 citations, November 2007 in “Journal of Investigative Dermatology”

Fluocinolone acetonide slows down hair follicle stem cells but speeds up skin cell growth in mice.

research Basal Keratinocytes Exhibit Age-Related Epigenetic and Transcriptomic Alterations Resulting in an Altered Metabolic Profile

April 2023 in “Journal of Investigative Dermatology”

Aging changes skin cells, leading to different DNA methylation and gene activity, affecting cell metabolism and aging signs.

research Rescuing Key Native Traits in Cultured Dermal Papilla Cells for Human Hair Regeneration

30 citations, November 2020 in “Journal of Advanced Research”

Conditioned medium from keratinocytes can improve hair growth potential in cultured dermal papilla cells.

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community He used Dutasteride for 20 YEARS: TL;DR Slight gains and largely stable for 20 years.

in Treatment 26 upvotes 11 months ago

John has experienced slight hair gains and stability over 20 years using Dutasteride, which is more effective than Finasteride in reducing scalp DHT and maintaining hair. Dutasteride at 0.5mg daily has a similar side effect profile to Finasteride, but at higher doses, it may increase the risk of sexual side effects.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community Dutasteride Isn't Working? Get a Scalp Biopsy NOW

in Finasteride/Dutasteride 19 upvotes 1 week ago

Dutasteride may not be effective for everyone due to underlying issues, suggesting scalp biopsies for further diagnosis. Users discuss using higher doses of dutasteride, topical treatments, minoxidil, and pyrilutamide for hair loss management.

community does lowering your prolactin levels regrow hair?

in Research/Science 9 upvotes 2 years ago

The potential of lowering prolactin levels to regrow hair, with a reference to Bayer's drug HMI 115 which has been indicated as having this effect. Treatments mentioned include Minoxidil and Finasteride, as well as RU58841.

community Been on dut 0.5mg daily for 12 months. I am cooked.

in Progress Pictures 10 upvotes 6 months ago

A user took finasteride for six months, then switched to dutasteride for a year, increasing the dosage over time, but hair shedding worsened. Replies suggest the issue is male pattern baldness and DHT-related.

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