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Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

Topical tretinoin can increase the absorption of minoxidil by three times, which may enhance its effectiveness for hair loss treatment. Tretinoin causes increased skin turnover, making the skin more permeable and potentially improving minoxidil's efficacy.

A user shared progress pictures showing significant hair regrowth after using 1mg finasteride daily and Kirkland 5% minoxidil twice a day since 05/02/2024, along with occasional microneedling. The user reported initial headaches but no longer experiences them.

The user uses finasteride, minoxidil, Nizoral, and dermarolling along with various supplements, oils, and shampoos to combat hair loss. They adjusted their routine based on feedback, changing dermarolling to once a week and reducing zinc intake due to side effects.

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.