Accelerated Senescence in Skin in a Murine Model of Radiation-Induced Multi-Organ Injury
February 2017
in “
Journal of radiation research
”
New to collagen? There is a guide in the encyclopedia. Read the guide → radiation-induced skin injury C57BL/6 mice high-dose radiation inflammation erythema dry desquamation ulceration mast cell infiltration fibrosis collagen deposition human keratinocyte cultures p21/waf1 senescence marker apoptosis activated caspase-3 immunohistochemistry epithelial stem cells hair follicles radiation skin injury redness skin peeling skin ulcers mast cells skin fibrosis collagen skin cell cultures p21 cell aging marker cell death caspase-3 stem cells hair roots
Studysummary This study found that high-dose radiation can induce accelerated cellular senescence, inflammation, and loss of epithelial stem cells in mouse and human skin, contributing to radiation dermatitis.
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