An Ear Punch Model for Studying the Effect of Radiation on Wound Healing

    April 2011 in “ International Journal of Radiation Biology ”
    Divino Deoliveira, Yiqun Jiao, Joel Ross, Kayla Corbin, Qizhen Xiao, Greta Toncheva, Colin Anderson-Evans, Terry T. Yoshizumi, Benny J. Chen, Nelson J. Chao
    Image of study
    TLDR Radiation significantly slows down wound healing in mice.
    In the 2011 study, researchers developed a mouse ear punch model to study the effects of radiation on wound healing. They used two mouse strains, MRL/MpJ and C57BL/6, and created 2 mm surgical wounds on the mice's ears, followed by local radiation. The study found that radiation significantly delayed wound healing in a dose-dependent manner. For instance, non-irradiated MRL/MpJ mice wounds healed 90% in 21 days, while those irradiated with 7, 10, and 15 Gy took 28, 70, and over 100 days, respectively. The addition of sublethal whole-body irradiation further delayed healing. Histological analysis showed delayed wound repair and regeneration, and radiation-induced apoptosis in epidermal cells. The study, which included groups of four mice and was consistent across two experiments, concluded that the ear punch model is valuable for studying radiation's impact on wounds and could aid in developing medical countermeasures. Advanced microscopy techniques were used, and the study was supported by the National Institute of Health.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Sunlight: Does it Stimulate Hair Growth or Hair Loss?

      in Research/Science  61 upvotes 8 months ago
      The conversation discusses whether sunlight exposure affects hair growth or loss, with mixed anecdotes and theories but no clear consensus. Some suggest moderate sunlight can benefit hair by providing vitamin D, while others doubt its effectiveness compared to treatments like Minoxidil or finasteride.

      community Verteporfin trials in hair transplant patients begin

      in Transplants  42 upvotes 2 years ago
      A clinical trial for Verteporfin as a hair loss treatment, and the potential for greater progress in treatments for hair loss in the future. Common treatments such as Minoxidil, Finasteride and RU58841 were discussed.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Hair Loss Drugs Ranked in Order of Efficacy

      in Research/Science  67 upvotes 1 year ago
      Dutasteride is likely the most effective treatment for male pattern baldness, followed by finasteride and minoxidil in various forms and dosages. Users discuss personal experiences, dosages, and potential side effects, with some considering combining treatments for better results.

    Similar Research

    5 / 1000+ results