An Ear Punch Model for Studying the Effect of Radiation on Wound Healing

This study observed that in mice, small-scale x-ray irradiation resulted in uniquely rapid healing of hair follicles, differing from the hypertrophic and hyperplastic responses seen in larger irradiated areas.

This study found that high-dose radiation can induce accelerated cellular senescence, inflammation, and loss of epithelial stem cells in mouse and human skin, contributing to radiation dermatitis.

This study established a rat model of radiation-induced dermatitis using 90 Gy irradiation, which may aid in exploring new treatments and understanding the pathology, particularly highlighting autophagy regulation as a potential therapeutic target.

This study found that radiation negatively impacts the survival and proliferation of fibroblasts on human dermis transplants, but hair follicle pores enhance cell viability even after irradiation.

In this laboratory study, researchers observed that mouse vascular endothelial cells exhibit dynamic changes after exposure to ionizing radiation, including a transient endothelial subpopulation that facilitates vascular-epidermal communication and skin repair, with shifting roles in angiogenesis and immune surveillance over time.