Establishment and Characterization of a Radiation-Induced Dermatitis Rat Model

February 2019 in “ Journal of Cellular and Molecular Medicine ”

Xiaowu Sheng, Yue Zhou, Hui Wang, Yongyi Shen, Qianjin Liao, Zhi-Ren Rao, Fei‐Yan Deng, Luyuan Xie, Chao‐Ling Yao, Huangxing Mao, Zhiyan Liu, Mingjing Peng, Ying Long, Yong Zeng, Lei Xue, Nana Gao, Yu Kong, Xiao Zhou

radiation-induced dermatitis erythema desquamation ulceration hair follicle loss inflammatory cell infiltration collagen deposition fibrosis apoptosis autophagy skin damage skin peeling skin ulcers hair loss inflammation collagen buildup scarring cell death self-digestion

TLDR Researchers created a rat model to study skin damage caused by radiation, which could help develop new treatments.

The study established a radiation-induced dermatitis rat model using doses of 40 Gy and 90 Gy to replicate human radiation dermatitis, showing significant skin damage such as erythema, desquamation, ulceration, and hair follicle loss. Histological analysis confirmed increased inflammatory cell infiltration, collagen deposition, and fibrosis. The model demonstrated both acute and chronic skin reactions, with visible damage within 7 days and extensive hair loss by 12 weeks post-irradiation. The findings suggested that targeting apoptosis and autophagy could be potential therapeutic strategies for treating radiation-induced dermatitis. The study involved sample sizes ranging from 6 to 12 rats per group, providing a reliable platform for testing new therapeutic strategies.

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