Long And Short Non-Coding RNA And Radiation Response: A Review

    February 2021 in “ Translational research ”
    Jared M. May, Michelle A. Bylicky, Sunita Chopra, C. Norman Coleman, Molykutty J. Aryankalayil
    TLDR Non-coding RNAs could help detect and treat radiation damage.
    The review discussed the roles of long and short non-coding RNAs (ncRNAs) in cellular responses to radiation, highlighting their potential as biomarkers and therapeutic targets. It covered how ncRNAs like miRNAs and lncRNAs regulate gene expression, DNA damage response, and repair mechanisms, influencing radiosensitivity and radioresistance in various cancers. Key examples included lncRNA HOTAIR enhancing breast cancer radioresistance and lncRNA GAS5 increasing cervical cancer radiosensitivity. The review emphasized the need for further research to fully understand ncRNA mechanisms and explore their clinical applications in improving radiotherapy outcomes.
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