Long And Short Non-Coding RNA And Radiation Response: A Review

    July 2021 in “ Translational research ”
    Jared M. May, Michelle A. Bylicky, Sunita Chopra, C. Norman Coleman, Molykutty J. Aryankalayil
    TLDR Non-coding RNAs could help detect and treat radiation damage.
    The review discussed the roles of long and short non-coding RNAs (ncRNAs) in the cellular response to radiation, highlighting their potential as biomarkers for early detection and treatment of radiation damage. It covered the mechanisms by which ncRNAs modulated radiosensitivity and radioresistance in both normal and cancerous tissues. Specific examples included lncRNAs like HOTAIR, which increased radioresistance in breast cancer by targeting miR-218 and miR-449b-5p. The review emphasized the importance of further research to fully understand the therapeutic potential of ncRNAs in radiation response and their role in mitigating radiation-induced damage.
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